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Adaptor Related Protein Complex 2 Alpha 2 (AP2a2)

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ADTAB; CLAPA2; HIP9; HYPJ; Alpha-Adaptin C; Huntingtin Interacting Protein J; Clathrin-Associated/Assembly/Adaptor Protein,Large,Alpha 2; 100 kDa coated vesicle protein C

Adaptor Related Protein Complex 2 Alpha 2 (AP2a2)
CCC G105
HGNC 562
MGI 101920
PubMed 22174158
RGD 71015
UniProt O94973
Wiki AP2A2
By randomly sequencing cDNA clones from size-fractionated human brain cDNA libraries, Nagase et al. (1998) identified AP2A2, which they designated KIAA0899. The deduced 929-amino acid protein shares more than 97% sequence identity with rat alpha-adaptin. By RT-PCR analysis followed by ELISA for quantitation, they detected ubiquitous, low-to-moderate expression of KIAA0899, with highest levels in spinal cord and fetal and adult brain and lowest levels in spleen.
Using the N terminus of huntingtin (HTT) in a yeast 2-hybrid screen of a testis cDNA library, Faber et al. (1998) identified AP2A2, which they designated huntingtin yeast partner J (HYPJ). The predicted protein shares significant sequence identity with mouse alpha-adaptin C.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Adaptor Related Protein Complex 2 Alpha 2 (AP2a2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 5:355-364(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Huntingtin interacts with a family of WW domain proteins."Hum. Mol. Genet. 7:1463-1474(1998) [PubMed] [Europe PMC] [Abstract]
  6. "The huntingtin interacting protein HIP1 is a clathrin and alpha-adaptin-binding protein involved in receptor-mediated endocytosis."Hum. Mol. Genet. 10:1807-1817(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Adaptor protein complexes as the key regulators of protein sorting in the post-Golgi network."Cell Struct. Funct. 28:419-429(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Effect of clathrin heavy chain- and alpha-adaptin-specific small inhibitory RNAs on endocytic accessory proteins and receptor trafficking in HeLa cells."J. Biol. Chem. 278:45160-45170(2003) [PubMed] [Europe PMC] [Abstract]
  9. "Adaptors for clathrin coats: structure and function."Annu. Rev. Cell Dev. Biol. 20:153-191(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The adaptor complex AP-2 regulates post-endocytic trafficking through the non-clathrin Arf6-dependent endocytic pathway."J. Cell Sci. 121:4008-4017(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning."Nat. Cell Biol. 14:488-501(2012) [PubMed] [Europe PMC] [Abstract]
  13. "alphaTAT1 catalyses microtubule acetylation at clathrin-coated pits."Nature 502:567-570(2013) [PubMed] [Europe PMC] [Abstract]
  14. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]