Copine VI, Neuronal (CPNE6)

Copine-6 is a brain-specific member of the copine family, which is composed of calcium-dependent membrane-binding proteins. The gene product contains two N-terminal C2 domains, and one von Willebrand factor A domain. It may have a role in synaptic plasticity.CPNE6 is expressed exclusively in neurons of the hippocampus and in the main and accessory olfactory bulbs, where various forms of synaptic plasticity and memory formation occur. CPNE6 has a role in postsynaptic events, in contrast to the presynaptic roles of the double C2 domain proteins. A GST-fusion protein with the second C2 domain of copine VI showed calcium-dependent binding to phosphatidylserine, indicating that this domain is responsible for the calcium-dependent association of copine VI with the membrane.