Clathrin, Heavy Polypeptide Like 1 (CLTCL1)

Using a YAC clone containing the velocardiofacial syndrome (VCFS) critical region on chromosome 22q11 as a substrate for cDNA selection, Sirotkin et al. (1996) derived a cDNA, which they designated CLTD, that encodes a protein with a high degree of homology at the amino acid level to human rat and Drosophila clathrin heavy chain.

The CLTD protein is 7% divergent at the amino acid level from that of the human clathrin heavy chain gene (CLTC) located on chromosome 17q11-qter.The gene was cloned using a software-based exon-trapping approach based on sequencing of genomic DNA present in chromosome 22q11 contigs combined with the use of exon-prediction computer programs. Based on these findings, the authors proposed that CLTD may be considered a candidate meningioma tumor suppressor gene.