G Protein Coupled Receptor 21 (GPR21)

O'Dowd et al. (1997) mapped the GPR21 gene to 9q33 by fluorescence in situ hybridization.O'Dowd et al. (1997) reported the discovery of 4 novel human putative G protein-coupled receptor (GPR) genes. By screening an EST database, they identified cDNA sequences that partially encode 3 additional GPRs. These cDNA fragments were used to screen a genomic library to isolate the full-length coding region of the genes. This resulted in the isolation of genes GPR21, GPR22, and GPR23. The 4 encoded receptors share significant identity to each other and to other members of the receptor family.

By fluorescence in situ hybridization, O'Dowd et al. (1997) mapped GPR20 to 8q24.2-q24.3, GPR21 to 9q33, GPR22 to 7q22-q31.1, and GPR23 to Xq13-q21.1.