Gamma-Aminobutyric Acid A Receptor Gamma 3 (gABRg3)

Gamma-aminobutyric acid (GABA) receptors are a family of proteins involved in the GABAergic neurotransmission of the mammalian central nervous system. GABRG3 is a member of the GABA-A receptor gene family of heteromeric pentameric ligand-gated ion channels through which GABA, the major inhibitory neurotransmitter in the mammalian brain, acts. GABA-A receptors are the site of action of a number of important pharmacologic agents including barbiturates, benzodiazepines, and ethanol.

GABRG3 gene is 35 kb from the alpha-5 subunit gene which, in turn, is about 100 kb from the beta-3 subunit locus. The latter is located at the centromeric end of the cluster and is transcribed in the opposite direction of GABRG3 and GABRA5.