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Reticulon 3 (RTN3)

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HAP; ASYIP; NSPL2; NSPLII; RTN3-A1; Neuroendocrine-Specific Protein-Like 2; NSP-Like Protein II; ASY Interacting Protein; Homolog Of ASY Protein

Reticulon 3 (RTN3)
CCC F993
HGNC 10469
MGI 1339970
PubMed 19625507
RGD 620988
UniProt O95197
Wiki RTN3
The mRNA for RTN3 was approximately 3-fold more abundant in macula than in peripheral retina. The 2,527-bp cDNA encodes a predicted 236-amino acid protein that shows strong sequence similarity with other members of the RTN gene family. RTN3 is widely expressed in human tissues, with highest expression in the brain.BACE1 colocalized with RTN3 in neurons of human brain gray matter, and with RTN4 in oligodendrocytes in white matter.
Overexpression of RTN3 in vitro inhibited BACE1 activity and decreased amyloid precursor protein (APP) processing. The findings suggested that reticulon proteins are negative modulators of BACE1 activity, and that RTN3 specifically blocks access of BACE1 to APP within neurons.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 3 (RTN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Reticulon 3 (RTN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Reticulon 3 (RTN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Reticulon 3 (RTN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Reticulon 3 (RTN3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 3 (RTN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Reticulon 3 (RTN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Reticulon 3 (RTN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Reticulon 3 (RTN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Reticulon 3 (RTN3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Reticulon 3 (RTN3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Reticulon 3 (RTN3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Reticulon 3 (RTN3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Reticulon 3 (RTN3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Reticulon 3 (RTN3) ELISA Kit Customized Service Offer
  1. "Cloning of a novel member of the reticulon gene family (RTN3): gene structure and chromosomal localization to 11q13."Genomics 58:73-81(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Pro-apoptotic ASY/Nogo-B protein associates with ASYIP."J. Cell. Physiol. 196:312-318(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Overexpression of human reticulon 3 (hRTN3) in astrocytoma."Clin. Neuropathol. 23:1-7(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Identification of a new RTN3 transcript, RTN3-A1, and its distribution in adult mouse brain."Brain Res. Mol. Brain Res. 138:236-243(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries." DNA Res. 12:117-126(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "A reticular rhapsody: phylogenic evolution and nomenclature of the RTN/Nogo gene family."FASEB J. 17:1238-1247(2003) [PubMed] [Europe PMC] [Abstract]
  10. "Reticulon family members modulate BACE1 activity and amyloid-beta peptide generation."Nat. Med. 10:959-965(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Reticulon 3 is involved in membrane trafficking between the endoplasmic reticulum and Golgi."Biochem. Biophys. Res. Commun. 334:1198-1205(2005) [PubMed] [Europe PMC] [Abstract]
  12. "Tissue specificity and regulation of the N-terminal diversity of reticulon 3."Biochem. J. 385:125-134(2005) [PubMed] [Europe PMC] [Abstract]
  13. "Adaptor FADD is recruited by RTN3/HAP in ER-bound signaling complexes."Apoptosis 11:1923-1932(2006) [PubMed] [Europe PMC] [Abstract]
  14. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Reticulons RTN3 and RTN4-B/C interact with BACE1 and inhibit its ability to produce amyloid beta-protein."Eur. J. Neurosci. 24:1237-1244(2006) [PubMed] [Europe PMC] [Abstract]
  16. "Mapping of interaction domains mediating binding between BACE1 and RTN/Nogo proteins."J. Mol. Biol. 363:625-634(2006) [PubMed] [Europe PMC] [Abstract]
  17. "Reticulon 3 mediates Bcl-2 accumulation in mitochondria in response to endoplasmic reticulum stress."Apoptosis 12:319-328(2007) [PubMed] [Europe PMC] [Abstract]
  18. "Reticulon 3 binds the 2C protein of enterovirus 71 and is required for viral replication."J. Biol. Chem. 282:5888-5898(2007) [PubMed] [Europe PMC] [Abstract]
  19. "The membrane topology of RTN3 and its effect on binding of RTN3 to BACE1."J. Biol. Chem. 282:29144-29151(2007) [PubMed] [Europe PMC] [Abstract]
  20. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  21. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  22. "A class of dynamin-like GTPases involved in the generation of the tubular ER network."Cell 138:549-561(2009) [PubMed] [Europe PMC] [Abstract]
  23. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  24. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  25. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  26. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]