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Dual Specificity Phosphatase 16 (DUSP16)

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MKP7; MAPK Phosphatase-7; Mitogen-activated protein kinase phosphatase 7

Dual Specificity Phosphatase 16 (DUSP16)
CCC F986
HGNC 17909
MGI 1917936
PubMed 20551953
RGD 1310721
UniProt Q9BY84
Wiki DUSP16
Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues.
DUSP16 belongs to a class of DUSPs, designated MKPs, that dephosphorylate MAPK (mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. MKPs contain a highly conserved C-terminal catalytic domain and an N-terminal Cdc25-like (CH2) domain. MAPK activation cascades mediate various physiologic processes, including cellular proliferation, apoptosis, differentiation, and stress responses.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 16 (DUSP16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 16 (DUSP16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 16 (DUSP16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 16 (DUSP16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 16 (DUSP16) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 16 (DUSP16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 16 (DUSP16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 16 (DUSP16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 16 (DUSP16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 16 (DUSP16) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dual Specificity Phosphatase 16 (DUSP16) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dual Specificity Phosphatase 16 (DUSP16) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dual Specificity Phosphatase 16 (DUSP16) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dual Specificity Phosphatase 16 (DUSP16) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dual Specificity Phosphatase 16 (DUSP16) ELISA Kit Customized Service Offer
  1. "MKP-7, a novel mitogen-activated protein kinase phosphatase, functions as a shuttle protein."J. Biol. Chem. 276:39002-39011(2001) [PubMed] [Europe PMC] [Abstract]
  2. "MAPK phosphatase DUSP16/MKP-7, a candidate tumor suppressor for chromosome region 12p12-13, reduces BCR-ABL-induced transformation."Oncogene 22:7728-7736(2003) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:347-355(2000) [PubMed] [Europe PMC] [Abstract]
  4. "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Activation of ERK induces phosphorylation of MAPK phosphatase-7, a JNK specific phosphatase, at Ser-446."J. Biol. Chem. 278:32448-32456(2003) [PubMed] [Europe PMC] [Abstract]
  7. "Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2."J. Biol. Chem. 280:25651-25658(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "The structure of the rhodanese domain of the human 2 dual specificity phosphatase 16."Submitted (JUN-2009) to the PDB data bank