≡

Dynactin 4 (DCTN4)

[Edit]

Dynactin subunit p62

Dynactin 4 (DCTN4)
CCC F964
HGNC 15518
MGI 1914915
PubMed 22772370
RGD 71023
UniProt Q9UJW0
Wiki DCTN4
DCTN4 belongs to the dynactin subunit 4 family.Member of the pointed-end complex of the dynactin shoulder complex which contains DCTN4, DCTN5 and DCTN6 subunits and ACTR10 (By similarity). Binds directly to the ACTR1A subunit of dynactin.Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.Cytoplasm, cytoskeleton. Centrosome. Overexpression does not disrupt microtubule organization or the integrity of the Golgi but does cause both cytosolic and nuclear distribution, suggesting that this polypeptide may be targeted to the nucleus at very high expression levels.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 4 (DCTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 4 (DCTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 4 (DCTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 4 (DCTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 4 (DCTN4) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 4 (DCTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 4 (DCTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 4 (DCTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 4 (DCTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 4 (DCTN4) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 4 (DCTN4) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 4 (DCTN4) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 4 (DCTN4) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 4 (DCTN4) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 4 (DCTN4) ELISA Kit Customized Service Offer
  1. "A dynactin subunit with a highly conserved cysteine-rich motif interacts directly with Arp1."J. Biol. Chem. 275:4834-4839(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Copper-dependent interaction of dynactin subunit p62 with the N terminus of ATP7B but not ATP7A."J. Biol. Chem. 281:14006-14014(2006) [PubMed] [Europe PMC] [Abstract]
  6. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  9. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]