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Dynactin 1 (DCTN1)

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DAP-150; DP-150; P135; p150,Glued Homolog; 150 kDa dynein-associated polypeptide

Dynactin 1 (DCTN1)
CCC F961
HGNC 2711
MGI 107745
PubMed 24343258
RGD 62038
UniProt Q14203
Wiki DCTN1
Dynactin subunit 1 is a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. This subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms. Mutations in this gene cause distal hereditary motor neuronopathy type VIIB (HMN7B) .

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 1 (DCTN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 1 (DCTN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 1 (DCTN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 1 (DCTN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 1 (DCTN1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 1 (DCTN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 1 (DCTN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 1 (DCTN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 1 (DCTN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 1 (DCTN1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Dynactin 1 (DCTN1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Dynactin 1 (DCTN1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Dynactin 1 (DCTN1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Dynactin 1 (DCTN1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Dynactin 1 (DCTN1) ELISA Kit Customized Service Offer
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  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "FBXL5 interacts with p150Glued and regulates its ubiquitination."Biochem. Biophys. Res. Commun. 359:34-39(2007) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "The retromer component SNX6 interacts with dynactin p150(Glued) and mediates endosome-to-TGN transport."Cell Res. 19:1334-1349(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  14. "A protein interaction network for Ecm29 links the 26 S proteasome to molecular motors and endosomal components."J. Biol. Chem. 285:31616-31633(2010) [PubMed] [Europe PMC] [Abstract]
  15. "A novel human dynactin-associated protein, dynAP, promotes activation of Akt, and ergosterol-related compounds induce dynAP-dependent apoptosis of human cancer cells."Mol. Cancer Ther. 9:2934-2942(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Neuronal ceroid lipofuscinosis protein CLN3 interacts with motor proteins and modifies location of late endosomal compartments."Cell. Mol. Life Sci. 69:2075-2089(2012) [PubMed] [Europe PMC] [Abstract]
  18. "The centriolar satellite protein Cep131 is important for genome stability."J. Cell Sci. 125:4770-4779(2012) [PubMed] [Europe PMC] [Abstract]
  19. "MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression."J. Cell Biol. 200:773-787(2013) [PubMed] [Europe PMC] [Abstract]
  20. "Cep126 is required for pericentriolar satellite localisation to the centrosome and for primary cilium formation."Biol. Cell 106:254-267(2014) [PubMed] [Europe PMC] [Abstract]
  21. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  22. "Structural basis for the activation of microtubule assembly by the EB1 and p150Glued complex."Mol. Cell 19:449-460(2005) [PubMed] [Europe PMC] [Abstract]
  23. "Solution structure of the CAP-Gly domain in human dynactin 1."Submitted (NOV-2005) to the PDB data bank
  24. "Key interaction modes of dynamic +TIP networks."Mol. Cell 23:663-671(2006) [PubMed] [Europe PMC] [Abstract]
  25. "Structure-function relationship of CAP-Gly domains."Nat. Struct. Mol. Biol. 14:959-967(2007) [PubMed] [Europe PMC] [Abstract]
  26. "CLIP170 autoinhibition mimics intermolecular interactions with p150Glued or EB1."Nat. Struct. Mol. Biol. 14:980-981(2007) [PubMed] [Europe PMC] [Abstract]
  27. "Mutant dynactin in motor neuron disease."Nat. Genet. 33:455-456(2003) [PubMed] [Europe PMC] [Abstract]
  28. "Point mutations of the p150 subunit of dynactin (DCTN1) gene in ALS."Neurology 63:724-726(2004) [PubMed] [Europe PMC] [Abstract]
  29. "Heterozygous R1101K mutation of the DCTN1 gene in a family with ALS and FTD."Ann. Neurol. 58:777-780(2005) [PubMed] [Europe PMC] [Abstract]
  30. "A motor neuron disease-associated mutation in p150Glued perturbs dynactin function and induces protein aggregation."J. Cell Biol. 172:733-745(2006) [PubMed] [Europe PMC] [Abstract]
  31. "DCTN1 mutations in Perry syndrome." Nat. Genet. 41:163-165(2009) [PubMed] [Europe PMC] [Abstract]
  32. "Characterization of DCTN1 genetic variability in neurodegeneration." Neurology 72:2024-2028(2009) [PubMed] [Europe PMC] [Abstract]
  33. "Neurodegeneration mutations in dynactin impair dynein-dependent nuclear migration."Proc. Natl. Acad. Sci. U.S.A. 106:5147-5152(2009) [PubMed] [Europe PMC] [Abstract]
  34. "Whole-exome sequencing in patients with inherited neuropathies: outcome and challenges."J. Neurol. 261:970-982(2014) [PubMed] [Europe PMC] [Abstract]
  35. "A Novel DCTN1 mutation with late-onset parkinsonism and frontotemporal atrophy."Mov. Disord. 29:1201-1204(2014) [PubMed] [Europe PMC] [Abstract]
  36. "Three families with Perry syndrome from distinct parts of the world."Parkinsonism Relat. Disord. 20:884-888(2014) [PubMed] [Europe PMC] [Abstract]