Nesprin 2 (Nesp2)

[Edit]

SYNE2; NUA; NUANCE; SYNE-2; Synaptic nuclear envelope protein 2; Nuclear envelope spectrin repeat protein 2; Nucleus and actin connecting element protein

Nesprin 2 (Nesp2)

SYNE2 is a nuclear outer membrane protein that binds cytoplasmic F-actin. This binding tethers the nucleus to the cytoskeleton and aids in the maintenance of the structural integrity of the nucleus. Several transcript variants encoding different isoforms have been found for this gene. SYNE2 contains multiple spectrin repeats and a 60-amino acid C-terminal region homologous to the Drosophila protein Klarsicht. RT-PCR analysis showed low to moderate expression of 2 SYNE2 splice variants in most tissues examined, including skeletal and cardiac muscle, kidney, liver, pancreas, and placenta, and indicated that alternative splicing patterns are conserved between SYNE1 and SYNE2.Nesprin-2-gamma also has a bipartite nuclear localization signal and a leucine zipper motif.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF952Hu01 Recombinant Nesprin 2 (Nesp2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF952Hu01 Polyclonal Antibody to Nesprin 2 (Nesp2) WB
MAF952Hu21 Monoclonal Antibody to Nesprin 2 (Nesp2) WB; IHC; ICC; IP.
Assay Kits SEF952Hu ELISA Kit for Nesprin 2 (Nesp2) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nesprin 2 (Nesp2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nesprin 2 (Nesp2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nesprin 2 (Nesp2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nesprin 2 (Nesp2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nesprin 2 (Nesp2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nesprin 2 (Nesp2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nesprin 2 (Nesp2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nesprin 2 (Nesp2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nesprin 2 (Nesp2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nesprin 2 (Nesp2) ELISA Kit Customized Service Offer
  1. "NUANCE, a giant protein connecting the nucleus and actin cytoskeleton."J. Cell Sci. 115:3207-3222(2002) [PubMed] [Europe PMC] [Abstract]
  2. "Nesprins: a novel family of spectrin-repeat-containing proteins that localize to the nuclear membrane in multiple tissues."J. Cell Sci. 114:4485-4498(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The nesprins are giant actin-binding proteins, orthologous to Drosophila melanogaster muscle protein MSP-300."Genomics 80:473-481(2002) [PubMed] [Europe PMC] [Abstract]
  4. "Multiple novel nesprin-1 and nesprin-2 variants act as versatile tissue-specific intracellular scaffolds."PLoS ONE 7:E40098-E40098(2012) [PubMed] [Europe PMC] [Abstract]
  5. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."DNA Res. 9:99-106(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Nuclear membrane proteins with potential disease links found by subtractive proteomics."Science 301:1380-1382(2003) [PubMed] [Europe PMC] [Abstract]
  13. "Nesprin-2 is a multi-isomeric protein that binds lamin and emerin at the nuclear envelope and forms a subcellular network in skeletal muscle."J. Cell Sci. 118:673-687(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Structural requirements for the assembly of LINC complexes and their function in cellular mechanical stiffness."Exp. Cell Res. 314:1892-1905(2008) [PubMed] [Europe PMC] [Abstract]
  15. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Nesprin-2 interacts with meckelin and mediates ciliogenesis via remodelling of the actin cytoskeleton."J. Cell Sci. 122:2716-2726(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  18. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  19. "Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes."J. Biol. Chem. 285:3487-3498(2010) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  21. "Linear arrays of nuclear envelope proteins harness retrograde actin flow for nuclear movement."Science 329:956-959(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  23. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  24. "Large-scale modelling of the divergent spectrin repeats in nesprins: giant modular proteins."PLoS ONE 8:E63633-E63633(2013) [PubMed] [Europe PMC] [Abstract]
  25. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  26. "Nesprins: tissue-specific expression of epsilon and other short isoforms."PLoS ONE 9:E94380-E94380(2014) [PubMed] [Europe PMC] [Abstract]
  27. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
  28. "Nesprin-1 and -2 are involved in the pathogenesis of Emery Dreifuss muscular dystrophy and are critical for nuclear envelope integrity."Hum. Mol. Genet. 16:2816-2833(2007) [PubMed] [Europe PMC] [Abstract]