Spectrin Beta, Non Erythrocytic 5 (SPTbN5)

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HUSPECV; BSPECV; HUBSPECV; Beta-V spectrin

Spectrin Beta, Non Erythrocytic 5 (SPTbN5)
SPTBN5 is most similar to the Drosophila beta-H spectrin and contains 1 partial and 29 complete spectrin repeats (106-amino acid repetitive units composed of 3 alpha helices). SPTBN5 has a modestly conserved actin-binding domain, a conserved membrane-association domain-1, a conserved self-association domain, and a C-terminal pleckstrin homology domain. The putative ankyrin-binding domain of SPTBN5 is poorly conserved and may be inactive. SPTBN5 expression at very low levels in many human tissues, with strongest expression in cerebellum, spinal cord, stomach, pituitary gland, liver, pancreas, salivary gland, kidney, bladder, and heart. Indirect immunofluorescence showed expression of Bspecv in rat retina in the outer segments of photoreceptor rods and cones and in stomach in cytosol of gastric epithelial cells.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spectrin Beta, Non Erythrocytic 5 (SPTbN5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 5 (SPTbN5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 5 (SPTbN5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spectrin Beta, Non Erythrocytic 5 (SPTbN5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spectrin Beta, Non Erythrocytic 5 (SPTbN5) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Spectrin Beta, Non Erythrocytic 5 (SPTbN5) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Spectrin Beta, Non Erythrocytic 5 (SPTbN5) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Spectrin Beta, Non Erythrocytic 5 (SPTbN5) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Spectrin Beta, Non Erythrocytic 5 (SPTbN5) CLIA Kit Customized Service Offer
n/a ELISA Kit for Spectrin Beta, Non Erythrocytic 5 (SPTbN5) ELISA Kit Customized Service Offer
  1. "Identification and characterization of beta V spectrin, a mammalian ortholog of Drosophila beta H spectrin."J. Biol. Chem. 275:21385-21395(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Analysis of the DNA sequence and duplication history of human chromosome 15." Nature 440:671-675(2006) [PubMed] [Europe PMC] [Abstract]
  3. "The spectrin cytoskeleton influences the surface expression and activation of human transient receptor potential channel 4 channels."J. Biol. Chem. 283:4395-4407(2008) [PubMed] [Europe PMC] [Abstract]