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Sulfatase Modifying Factor 2 (SUMF2)

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pFGE; C-alpha-formylglycine-generating enzyme 2

Sulfatase Modifying Factor 2 (SUMF2)
CCC F936
HGNC 20415
MGI 1915152
PubMed 15962010
RGD 1563253
UniProt Q8NBJ7
Wiki SUMF2
The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly). The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum.
Sulfatase Modifying Factor 2 has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sulfatase Modifying Factor 2 (SUMF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sulfatase Modifying Factor 2 (SUMF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sulfatase Modifying Factor 2 (SUMF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sulfatase Modifying Factor 2 (SUMF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sulfatase Modifying Factor 2 (SUMF2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sulfatase Modifying Factor 2 (SUMF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sulfatase Modifying Factor 2 (SUMF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sulfatase Modifying Factor 2 (SUMF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sulfatase Modifying Factor 2 (SUMF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sulfatase Modifying Factor 2 (SUMF2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sulfatase Modifying Factor 2 (SUMF2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sulfatase Modifying Factor 2 (SUMF2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sulfatase Modifying Factor 2 (SUMF2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sulfatase Modifying Factor 2 (SUMF2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sulfatase Modifying Factor 2 (SUMF2) ELISA Kit Customized Service Offer
  1. "The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases."Cell 113:445-456(2003) [PubMed] [Europe PMC] [Abstract]
  2. "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment." Genome Res. 13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
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  6. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Expression, localization, structural, and functional characterization of pFGE, the paralog of the Calpha-formylglycine-generating enzyme."J. Biol. Chem. 280:15173-15179(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Sulphatase activities are regulated by the interaction of sulphatase-modifying factor 1 with SUMF2."EMBO Rep. 6:655-660(2005) [PubMed] [Europe PMC] [Abstract]
  10. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human pFGE, the paralog of the Calpha-formylglycine-generating enzyme."J. Biol. Chem. 280:15180-15187(2005) [PubMed] [Europe PMC] [Abstract]
  12. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]