≡

Ribonucleotide Reductase M2 (RRM2)

[Edit]

RR2; Ribonucleotide reductase small chain

Ribonucleotide Reductase M2 (RRM2)
CCC F915
HGNC 10452
MGI 98181
PubMed 24423925
RGD 1598310
UniProt P31350
Wiki RRM2
RRM2 encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
The deduced 389-amino acid RRM2 protein has a molecular mass of 45 kD and is 1 amino acid shorter than the equivalent mouse protein. The human and mouse RRM2 proteins share 96% homology in the C terminus, but only 69% in the first 68 residues in the N terminus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonucleotide Reductase M2 (RRM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonucleotide Reductase M2 (RRM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonucleotide Reductase M2 (RRM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonucleotide Reductase M2 (RRM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonucleotide Reductase M2 (RRM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonucleotide Reductase M2 (RRM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonucleotide Reductase M2 (RRM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonucleotide Reductase M2 (RRM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonucleotide Reductase M2 (RRM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonucleotide Reductase M2 (RRM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Ribonucleotide Reductase M2 (RRM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Ribonucleotide Reductase M2 (RRM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Ribonucleotide Reductase M2 (RRM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Ribonucleotide Reductase M2 (RRM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Ribonucleotide Reductase M2 (RRM2) ELISA Kit Customized Service Offer
  1. "Sequence analysis of the large and small subunits of human ribonucleotide reductase."DNA Seq. 2:227-234(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Characterization of the human ribonucleotide reductase M2 subunit gene; genomic structure and promoter analyses."Cytogenet. Cell Genet. 95:52-59(2001) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra."J. Proteome Res. 6:4150-4162(2007) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction."Mol. Cell. Proteomics 6:1952-1967(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]