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Sperm Associated Antigen 8 (SPAG8)

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SMP1; BS-84; HSD-1; SPAG3; hSMP-1; Sperm membrane protein 1; Sperm membrane protein BS-84

Sperm Associated Antigen 8 (SPAG8)
CCC F908
HGNC 14105
MGI 3056295
PubMed 10500252
RGD 1307079
UniProt Q99932
Wiki SPAG8
The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens.
Sperm Associated Antigen 8 is recognized by sperm agglutinating antibodies from an infertile woman. This protein is localized in germ cells of the testis at all stages of spermatogenesis and is localized to the acrosomal region of mature spermatozoa. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 8 (SPAG8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 8 (SPAG8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 8 (SPAG8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 8 (SPAG8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 8 (SPAG8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 8 (SPAG8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 8 (SPAG8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 8 (SPAG8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 8 (SPAG8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 8 (SPAG8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Sperm Associated Antigen 8 (SPAG8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Sperm Associated Antigen 8 (SPAG8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Sperm Associated Antigen 8 (SPAG8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Sperm Associated Antigen 8 (SPAG8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Sperm Associated Antigen 8 (SPAG8) ELISA Kit Customized Service Offer
  1. "Expression and characterization of a novel human sperm membrane protein."Biol. Reprod. 54:323-330(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Assignment of chromosomal locus and evidence for alternatively spliced mRNAs of a human sperm membrane protein (hSMP-1)."Biochim. Biophys. Acta 1447:119-124(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "DNA sequence and analysis of human chromosome 9." Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Sperm membrane protein (hSMP-1) and RanBPM complex in the microtubule-organizing centre."J. Mol. Med. 82:383-388(2004) [PubMed] [Europe PMC] [Abstract]