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Septin 11 (SEPT11)

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Septin 11 (SEPT11)
CCC F871
HGNC 25589
MGI 1277214
PubMed 11790298
RGD 1307405
UniProt Q9NVA2
Wiki SEPT11
SEPT11 belongs to the conserved septin family of filament-forming cytoskeletal GTPases that are involved in a variety of cellular functions including cytokinesis and vesicle trafficking.The deduced 429-amino acid protein has a unique N-terminal region followed by a conserved GTPase domain and a C-terminal domain. Northern blot analysis detected SEPT11 expression in all tissues examined except leukocytes, with transcripts of 6.5, 3.0, and 2.0 kb expressed in a tissue-specific manner. Western blot analysis detected SEPT11 at an apparent molecular mass of 48 kD in rat brain and in several mammalian cell lines, including human. Endogenous SEPT11 localized to short filaments in HeLa and COS-7 cells, and SEPT11 colocalized with microtubule or actin cytoskeletal elements in other cell lines in a cell type-dependent manner.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 11 (SEPT11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 11 (SEPT11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 11 (SEPT11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 11 (SEPT11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 11 (SEPT11) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 11 (SEPT11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 11 (SEPT11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 11 (SEPT11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 11 (SEPT11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 11 (SEPT11) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 11 (SEPT11) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 11 (SEPT11) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 11 (SEPT11) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 11 (SEPT11) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 11 (SEPT11) ELISA Kit Customized Service Offer
  1. "Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins."Mol. Cell. Proteomics 9:2517-2528(2010) [PubMed] [Europe PMC] [Abstract]
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  7. , Submitted (DEC-2008) to UniProtKB
  8. "Biochemical and cell biological characterization of a mammalian septin, Sept11."FEBS Lett. 568:83-88(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11."J. Biol. Chem. 279:55895-55904(2004) [PubMed] [Europe PMC] [Abstract]
  10. "FLJ10849, a septin family gene, fuses MLL in a novel leukemia cell line CNLBC1 derived from chronic neutrophilic leukemia in transformation with t(4;11)(q21;q23)."Leukemia 18:998-1005(2004) [PubMed] [Europe PMC] [Abstract]
  11. "Expression profiling the human septin gene family."J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
  12. "SEPT9 sequence alternations causing hereditary neuralgic amyotrophy are associated with altered interactions with SEPT4/SEPT11 and resistance to Rho/Rhotekin-signaling."Hum. Mutat. 28:1005-1013(2007) [PubMed] [Europe PMC] [Abstract]
  13. "SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells."J. Biochem. Mol. Biol. 40:973-978(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Septin 11 restricts InlB-mediated invasion by Listeria."J. Biol. Chem. 284:11613-11621(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Septins regulate bacterial entry into host cells."PLoS ONE 4:E4196-E4196(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]