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Septin 7 (SEPT7)

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CDC10; CDC3; SEPT7A; CDC10 protein homolog

Septin 7 (SEPT7)
CCC F867
HGNC 1717
MGI 1335094
PubMed 8037772
RGD 620469
UniProt Q16181
Wiki SEPT7
Septin-7 is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif.
The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. Although the exact function of this gene has not yet been determined, its high similarity to yeast CDC10 and the high conservative nature of eukaryotic cell cycle machinery suggest a similar role to that of its yeast counterpart. Alternative splicing results in two transcript variants encoding different isoforms.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 7 (SEPT7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 7 (SEPT7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 7 (SEPT7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 7 (SEPT7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 7 (SEPT7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 7 (SEPT7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 7 (SEPT7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 7 (SEPT7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 7 (SEPT7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 7 (SEPT7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 7 (SEPT7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 7 (SEPT7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 7 (SEPT7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 7 (SEPT7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 7 (SEPT7) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel human cDNA homologous to CDC10 in Saccharomyces cerevisiae."Biochem. Biophys. Res. Commun. 202:82-87(1994) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Biochemical and cell biological analyses of a mammalian septin complex, Sept7/9b/11."J. Biol. Chem. 279:55895-55904(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Expression profiling the human septin gene family."J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4."Mol. Biol. Cell 16:4648-4659(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Structural analysis of septin 2, 6, and 7 complexes."J. Biol. Chem. 281:30697-30706(2006) [PubMed] [Europe PMC] [Abstract]
  9. "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7."Cell 130:837-850(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Septin 7 interacts with centromere-associated protein E and is required for its kinetochore localization."J. Biol. Chem. 283:18916-18925(2008) [PubMed] [Europe PMC] [Abstract]
  11. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Septins regulate bacterial entry into host cells."PLoS ONE 4:E4196-E4196(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  15. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  17. "Structural insight into filament formation by mammalian septins."Nature 449:311-315(2007) [PubMed] [Europe PMC] [Abstract]