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Septin 6 (SEPT6)

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SEP2

Septin 6 (SEPT6)
CCC F866
HGNC 15848
MGI 1888939
PubMed 8590280
RGD 1585082
UniProt Q14141
Wiki SEPT6
Septin-6 is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.
The deduced 424-amino acid protein shares 40% identity with CDC10 (SEPT7) and contains an ATP/GTP-binding site motif. Northern blot analysis detected nearly ubiquitous expression, with highest level in thymus.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF866Hu01 Recombinant Septin 6 (SEPT6) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF866Hu01 Polyclonal Antibody to Septin 6 (SEPT6) WB; IHC; ICC; IP.
MAF866Hu21 Monoclonal Antibody to Septin 6 (SEPT6) WB; IHC; ICC; IP.
Assay Kits SEF866Hu ELISA Kit for Septin 6 (SEPT6) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 6 (SEPT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 6 (SEPT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 6 (SEPT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 6 (SEPT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 6 (SEPT6) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Septin 6 (SEPT6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Septin 6 (SEPT6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Septin 6 (SEPT6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Septin 6 (SEPT6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Septin 6 (SEPT6) ELISA Kit Customized Service Offer
  1. "SEPTIN6, a human homologue to mouse Septin6, is fused to MLL in infant acute myeloid leukemia with complex chromosomal abnormalities involving 11q23 and Xq24."Cancer Res. 62:333-337(2002) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."Nat. Biotechnol. 21:566-569(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  6. "Expression profiling the human septin gene family."J. Pathol. 206:269-278(2005) [PubMed] [Europe PMC] [Abstract]
  7. "Mammalian septins regulate microtubule stability through interaction with the microtubule-binding protein MAP4."Mol. Biol. Cell 16:4648-4659(2005) [PubMed] [Europe PMC] [Abstract]
  8. "A mitotic septin scaffold required for mammalian chromosome congression and segregation."Science 307:1781-1785(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Structural analysis of septin 2, 6, and 7 complexes."J. Biol. Chem. 281:30697-30706(2006) [PubMed] [Europe PMC] [Abstract]
  10. "Septins regulate actin organization and cell-cycle arrest through nuclear accumulation of NCK mediated by SOCS7."Cell 130:837-850(2007) [PubMed] [Europe PMC] [Abstract]
  11. "SEPT12 interacts with SEPT6 and this interaction alters the filament structure of SEPT6 in Hela cells."J. Biochem. Mol. Biol. 40:973-978(2007) [PubMed] [Europe PMC] [Abstract]
  12. "An RNA-binding protein, hnRNP A1, and a scaffold protein, septin 6, facilitate hepatitis C virus replication."J. Virol. 81:3852-3865(2007) [PubMed] [Europe PMC] [Abstract]
  13. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Septins regulate bacterial entry into host cells."PLoS ONE 4:E4196-E4196(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  19. "Structural insight into filament formation by mammalian septins."Nature 449:311-315(2007) [PubMed] [Europe PMC] [Abstract]