≡

Scaffold Attachment Factor B2 (SAFB2)

[Edit]

SAF-B2

Scaffold Attachment Factor B2 (SAFB2)
CCC F856
HGNC 21605
MGI 2146808
PubMed 22566185
UniProt Q14151
Wiki SAFB2
SAFB2 encodes a deduced 953-amino acid protein with 75% homology to SAFB. Both SAFB and SAFB2 contain a highly conserved SAF box and RRM domain and both contain a nuclear localization signal. SAFB2 functions as an estrogen receptor corepressor and that its overexpression results in inhibition of proliferation. SAFB and SAFB2 interact directly through a C-terminal domain, resulting in additive repression activity. Whereas SAFB is exclusively nuclear, SAFB2 is found in the cytoplasm as well as in the nucleus. Transfection experiments detected interaction between SAFB2 and vinexin, a protein involved in linking signaling to the cytoskeleton. SAFB1 and SAFB2 are crucial repressors for ERα dynamics in association with the nuclear matrix and that their synergistic regulation of ERα mobility is sufficient for inhibiting ERα function.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scaffold Attachment Factor B2 (SAFB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scaffold Attachment Factor B2 (SAFB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scaffold Attachment Factor B2 (SAFB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scaffold Attachment Factor B2 (SAFB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scaffold Attachment Factor B2 (SAFB2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Scaffold Attachment Factor B2 (SAFB2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Scaffold Attachment Factor B2 (SAFB2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Scaffold Attachment Factor B2 (SAFB2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Scaffold Attachment Factor B2 (SAFB2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Scaffold Attachment Factor B2 (SAFB2) ELISA Kit Customized Service Offer
  1. "Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1."DNA Res. 2:167-174(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and biology of human chromosome 19." Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "SAFB2, a new scaffold attachment factor homolog and estrogen receptor corepressor."J. Biol. Chem. 278:20059-20068(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  7. "Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment."J. Proteome Res. 7:5167-5176(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  10. "The enzymatic activity of SR protein kinases 1 and 1a is negatively affected by interaction with scaffold attachment factors B1 and 2."FEBS J. 276:5212-5227(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  14. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  15. "Co-repressor activity of scaffold attachment factor B1 requires sumoylation."Biochem. Biophys. Res. Commun. 408:516-522(2011) [PubMed] [Europe PMC] [Abstract]
  16. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  17. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]