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Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2)

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EREG1; KNP3; LTRPC2; NUDT9H; TRPC7; Estrogen-responsive element-associated gene 1; Long transient receptor potential channel 2; Transient receptor potential channel 7

Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2)
CCC F832
HGNC 12339
MGI 1351901
PubMed 23511475
RGD 1311889
UniProt O94759
Wiki TRPM2
TRPM2 highly expressed in the brain and was implicated by both genetic linkage studies in families and then by case control or trio allelic association studies in the genetic aetiology of bipolar affective disorder . The physiological role of TRPM2 is not well understood. It was shown to be involved in insulin secretion. The protein encoded by this gene is a non-selective calcium-permeable cation channel and is part of the Transient Receptor Potential ion channel super family. The closest relative is the cold and menthol activated TRPM8 ion channel. While TRPM2 is not cold sensitive it is activated by heat. The TRPM2 ion channel is activated by free intracellular ADP-ribose in synergy with free intracellular calcium. ADP-Ribose is produced to by the enzyme PARP in response to oxidative stress and confers susceptibility to cell death.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Transient Receptor Potential Cation Channel Subfamily M, Member 2 (TRPM2) ELISA Kit Customized Service Offer
  1. "Molecular cloning of a novel putative Ca2+ channel protein (TRPC7) highly expressed in brain."Genomics 54:124-131(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Activation of the cation channel long transient receptor potential channel 2 (LTRPC2) by hydrogen peroxide. A splice variant reveals a mode of activation independent of ADP-ribose."J. Biol. Chem. 277:23150-23156(2002) [PubMed] [Europe PMC] [Abstract]
  3. "A novel TRPM2 isoform inhibits calcium influx and susceptibility to cell death."J. Biol. Chem. 278:16222-16229(2003) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of human and mouse TRPM2 genes: identification of a novel N-terminal truncated protein specifically expressed in human striatum."Biochem. Biophys. Res. Commun. 328:1232-1243(2005) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 21." Nature 405:311-319(2000) [PubMed] [Europe PMC] [Abstract]
  6. "ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology."Nature 411:595-599(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Immunocyte Ca2+ influx system mediated by LTRPC2."Science 293:1327-1330(2001) [PubMed] [Europe PMC] [Abstract]
  8. "LTRPC2 Ca2+-permeable channel activated by changes in redox status confers susceptibility to cell death."Mol. Cell 9:163-173(2002) [PubMed] [Europe PMC] [Abstract]