≡

Tensin 3 (TNS3)

[Edit]

TENS1; TEM6; TPP; Tumor Endothelial Marker 6; Tensin-Like SH2 Domain-Containing 1

Tensin 3 (TNS3)
CCC F819
HGNC 21616
MGI 2443012
PubMed 17643115
UniProt Q68CZ2
Tensin-3 formed a complex with focal adhesion kinase and p130Cas (BCAR1) in human breast carcinoma cells. Addition of EGF to these cells induced dephosphorylation of FAK and p130Cas, leading to dissociation of the tensin-3/FAK/p130Cas complex and enhanced interaction between tensin-3 and EGFR. The deduced 1,445-amino acid protein has a calculated molecular mass of 155.3 kD. Like other tensins, tensin-3 has an N-terminal actin-binding domain and C-terminal SH2 and PTB domains. It also has several potential tyrosine phosphorylation sites. Northern blot analysis detected high expression of an 8-kb transcript in kidney and placenta, with weaker expression in heart, skeletal muscle, spleen, liver, and lung. Western blot analysis revealed a 180-kD tensin-3 protein in human endothelial and epithelial cells and fibroblasts.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF819Hu01 Recombinant Tensin 3 (TNS3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF819Hu01 Polyclonal Antibody to Tensin 3 (TNS3) WB; IHC; ICC; IP.
MAF819Hu21 Monoclonal Antibody to Tensin 3 (TNS3) WB; IHC; ICC; IP.
Assay Kits SEF819Hu ELISA Kit for Tensin 3 (TNS3) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Tensin 3 (TNS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Tensin 3 (TNS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Tensin 3 (TNS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Tensin 3 (TNS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Tensin 3 (TNS3) ELISA Kit Customized Service Offer
  1. "Cell surface tumor endothelial markers are conserved in mice and humans."Cancer Res. 61:6649-6655(2001) [PubMed] [Europe PMC] [Abstract]
  2. "Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3."Mol. Cancer Res. 2:225-232(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs." Genome Res. 11:422-435(2001) [PubMed] [Europe PMC] [Abstract]
  5. "The DNA sequence of human chromosome 7." Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Tensin3 is a novel thyroid-specific gene."J. Mol. Endocrinol. 36:R1-R8(2006) [PubMed] [Europe PMC] [Abstract]
  8. "A reciprocal tensin-3-cten switch mediates EGF-driven mammary cell migration." Nat. Cell Biol. 9:961-969(2007) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  13. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  14. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  15. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  16. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]