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Anoctamin 7 (ANO7)

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PCANAP5; TMEM16G; NGEP; PCANAP5L; IPCA-5; D-TMPP; Dresden transmembrane protein of the prostate; New gene expressed in prostate; Prostate cancer-associated protein 5

Anoctamin 7 (ANO7)
CCC F814
HGNC 31677
MGI 3052714
RGD 1302987
UniProt Q6IWH7
The deduced 932-amino acid protein shares 76.7% amino acid identity with mouse Tmem16g. Other members of the TMEM16 protein family, including mouse Tmem16g, contain 8 transmembrane domains with cytoplasmic N and C termini, but human TMEM16G has only 7 transmembrane domains due to a thr844-to-asn substitution that causes misfolding of the eighth transmembrane domain. In silico analysis revealed TMEM16G expression in normal prostate, prostate cancer, iris, medulla, and HeLa cells.Higher molecular mass species were also detected, suggesting posttranslational modification. Immunolocalization of transfected cells showed the NGEP-S protein localized in the nucleus and cytoplasm and the NGEP-L protein localized on the plasma membrane.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 7 (ANO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 7 (ANO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 7 (ANO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 7 (ANO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 7 (ANO7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 7 (ANO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 7 (ANO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 7 (ANO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 7 (ANO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 7 (ANO7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Anoctamin 7 (ANO7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Anoctamin 7 (ANO7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Anoctamin 7 (ANO7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Anoctamin 7 (ANO7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Anoctamin 7 (ANO7) ELISA Kit Customized Service Offer
  1. "NGEP, a gene encoding a membrane protein detected only in prostate cancer and normal prostate."Proc. Natl. Acad. Sci. U.S.A. 101:3059-3064(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes."Genome Res. 9:1198-1203(1999) [PubMed] [Europe PMC] [Abstract]
  4. "Characterization of human TMEM16G gene in silico."Int. J. Mol. Med. 14:759-764(2004) [PubMed] [Europe PMC] [Abstract]
  5. "D-TMPP: a novel androgen-regulated gene preferentially expressed in prostate and prostate cancer that is the first characterized member of an eukaryotic gene family."Prostate 64:387-400(2005) [PubMed] [Europe PMC] [Abstract]
  6. "NGEP, a prostate-specific plasma membrane protein that promotes the association of LNCaP cells."Cancer Res. 67:1594-1601(2007) [PubMed] [Europe PMC] [Abstract]
  7. "Topology of NGEP, a prostate-specific cell:cell junction protein widely expressed in many cancers of different grade level."Cancer Res. 68:6306-6312(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Expression and function of epithelial anoctamins."J. Biol. Chem. 285:7838-7845(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Physiological roles and diseases of Tmem16/Anoctamin proteins: are they all chloride channels?"Acta Pharmacol. Sin. 32:685-692(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Anoctamins."Pflugers Arch. 462:195-208(2011) [PubMed] [Europe PMC] [Abstract]
  11. "ANOs 3-7 in the anoctamin/Tmem16 Cl- channel family are intracellular proteins."Am. J. Physiol. 302:C482-C493(2012) [PubMed] [Europe PMC] [Abstract]
  12. "The anoctamin (TMEM16) gene family: calcium-activated chloride channels come of age."Exp. Physiol. 97:175-176(2012) [PubMed] [Europe PMC] [Abstract]
  13. "The anoctamin family: TMEM16A and TMEM16B as calcium-activated chloride channels."Exp. Physiol. 97:177-183(2012) [PubMed] [Europe PMC] [Abstract]
  14. "Anoctamins are a family of Ca2+ activated Cl- channels."J. Cell Sci. 125:4991-4998(2012) [PubMed] [Europe PMC] [Abstract]