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Hepsin encodes a type II transmembrane serine protease. The encoded protein has an extracellular region that consists of two domains, a catalytic serine protease domain and a non-catalytic scavenger receptor cysteine-rich domain.
This protein may be involved in diverse cellular functions including blood coagulation, maintenance of cell morphology and the growth and progression of certain cancers, particularly prostate cancer. Alternative splicing results in multiple transcript variants.It is present in the plasma membrane in a molecular orientation of type II membrane-associated proteins, with its catalytic subunit (C-terminal half) at the cell surface and its N terminus facing the cytosol. Hepsin is not found in cytosol. See also TMPRSS2, a related serine protease.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hepsin (HPN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hepsin (HPN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hepsin (HPN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hepsin (HPN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hepsin (HPN) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hepsin (HPN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hepsin (HPN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hepsin (HPN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hepsin (HPN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hepsin (HPN) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Hepsin (HPN) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Hepsin (HPN) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Hepsin (HPN) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Hepsin (HPN) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Hepsin (HPN) | ELISA Kit Customized Service Offer |
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- "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
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- "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
- "TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein."J. Virol. 88:1293-1307(2014) [PubMed] [Europe PMC] [Abstract]
- "Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers."Biochem. J. 390:125-136(2005) [PubMed] [Europe PMC] [Abstract]