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Retinoblastoma Like Protein 1 (RBL1)

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PRB1; CP107; p107; 107 kDa retinoblastoma-associated protein

Retinoblastoma Like Protein 1 (RBL1)
CCC F774
HGNC 9893
MGI 103300
PubMed 24166509
RGD 1595511
UniProt P28749
Wiki RBL1
Retinoblastoma Like Protein 1 is similar in sequence and possibly function to the product of the retinoblastoma 1 (RB1) gene. The RB1 gene product is a tumor suppressor protein that appears to be involved in cell cycle regulation, as it is phosphorylated in the S to M phase transition and is dephosphorylated in the G1 phase of the cell cycle. Both the RB1 protein and the product of this gene can form a complex with adenovirus E1A protein and SV40 Large T-antigen, with the SV40 large T-antigen binding only to the unphosphorylated form of each protein. In addition, both proteins can inhibit the transcription of cell cycle genes containing E2F binding sites in their promoters. Due to the sequence and biochemical similarities with the RB1 protein, it is thought that the protein encoded by this gene may also be a tumor suppressor.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Like Protein 1 (RBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Like Protein 1 (RBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Like Protein 1 (RBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Like Protein 1 (RBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Like Protein 1 (RBL1) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Like Protein 1 (RBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Like Protein 1 (RBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Like Protein 1 (RBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Like Protein 1 (RBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Like Protein 1 (RBL1) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Like Protein 1 (RBL1) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Like Protein 1 (RBL1) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Like Protein 1 (RBL1) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Like Protein 1 (RBL1) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Like Protein 1 (RBL1) ELISA Kit Customized Service Offer
  1. "Inhibition of cell proliferation by p107, a relative of the retinoblastoma protein."Genes Dev. 7:1111-1125(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Molecular cloning, chromosomal mapping, and expression of the cDNA for p107, a retinoblastoma gene product-related protein."Cell 66:1155-1164(1991) [PubMed] [Europe PMC] [Abstract]
  6. "Differential roles of two tandem E2F sites in repression of the human p107 promoter by retinoblastoma and p107 proteins."Mol. Cell. Biol. 15:3552-3562(1995) [PubMed] [Europe PMC] [Abstract]
  7. "Reversal of growth suppression by p107 via direct phosphorylation by cyclin D1/cyclin-dependent kinase 4."Mol. Cell. Biol. 22:2242-2254(2002) [PubMed] [Europe PMC] [Abstract]
  8. "The cellular 107K protein that binds to adenovirus E1A also associates with the large T antigens of SV40 and JC virus."Cell 58:249-255(1989) [PubMed] [Europe PMC] [Abstract]
  9. "Differential specificity for binding of retinoblastoma binding protein 2 to RB, p107, and TATA-binding protein."Mol. Cell. Biol. 14:7256-7264(1994) [PubMed] [Europe PMC] [Abstract]
  10. "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb."Cancer Cell 2:387-399(2002) [PubMed] [Europe PMC] [Abstract]
  11. "Distinct phosphorylation events regulate p130- and p107-mediated repression of E2F-4."J. Biol. Chem. 277:26741-26752(2002) [PubMed] [Europe PMC] [Abstract]
  12. "Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release."Cell 123:1093-1106(2005) [PubMed] [Europe PMC] [Abstract]
  13. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]