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Retinoblastoma Like Protein 2 (RBL2)

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P130; Rb2; 130 kDa retinoblastoma-associated protein; Retinoblastoma-related protein 2

Retinoblastoma Like Protein 2 (RBL2)
CCC F773
HGNC 9894
MGI 105085
PubMed 18311151
RGD 3541
UniProt Q08999
Wiki RBL2
Mayol et al. (1993) cloned a retinoblastoma-related human gene, referred to as RB2, on the basis of sequence homology of the E1A-binding domain of the retinoblastoma gene (RB1). Structural homology with RB1 suggested a possible function of RB2 as a tumor suppressor gene. RBL2 has a molecular mass of about 120 kD.
Kong et al. (2006) found that RBL2 and RINT1 were essential for telomere length control in human fibroblasts, with loss of either protein leading to longer telomeres. They proposed that RBL2 forms a complex with RAD50 (604040) through RINT1 to block telomerase-independent telomere lengthening. Baldi et al. (1996) characterized the organization and 5-prime flanking region of the Rb2, or p130, gene. They determined that the gene contains 22 exons and spans over 50 kb.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Like Protein 2 (RBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Like Protein 2 (RBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Like Protein 2 (RBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Like Protein 2 (RBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Like Protein 2 (RBL2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Like Protein 2 (RBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Like Protein 2 (RBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Like Protein 2 (RBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Like Protein 2 (RBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Like Protein 2 (RBL2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Like Protein 2 (RBL2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Like Protein 2 (RBL2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Like Protein 2 (RBL2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Like Protein 2 (RBL2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Like Protein 2 (RBL2) ELISA Kit Customized Service Offer
  1. "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E."Genes Dev. 7:2366-2377(1993) [PubMed] [Europe PMC] [Abstract]
  2. "Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins."Genes Dev. 7:2378-2391(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain."Oncogene 8:2561-2566(1993) [PubMed] [Europe PMC] [Abstract]
  7. "Genomic structure of the human retinoblastoma-related Rb2/p130 gene."Proc. Natl. Acad. Sci. U.S.A. 93:4629-4632(1996) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphorylation of the retinoblastoma-related protein p130 in growth-arrested cells."Oncogene 19:5116-5122(2000) [PubMed] [Europe PMC] [Abstract]
  9. "Che-1 affects cell growth by interfering with the recruitment of HDAC1 by Rb."Cancer Cell 2:387-399(2002) [PubMed] [Europe PMC] [Abstract]
  10. "The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein-ubiquitin ligase SCF(Skp2)."Genes Dev. 16:2946-2957(2002) [PubMed] [Europe PMC] [Abstract]
  11. "The Rb-related p130 protein controls telomere lengthening through an interaction with a Rad50-interacting protein, RINT-1."Mol. Cell 22:63-71(2006) [PubMed] [Europe PMC] [Abstract]
  12. "LINC, a human complex that is related to pRB-containing complexes in invertebrates regulates the expression of G2/M genes."Cell Cycle 6:1903-1913(2007) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  16. "Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence."EMBO J. 31:95-109(2012) [PubMed] [Europe PMC] [Abstract]
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  18. "Diagnostic exome sequencing in persons with severe intellectual disability."N. Engl. J. Med. 367:1921-1929(2012) [PubMed] [Europe PMC] [Abstract]