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Retinoblastoma Binding Protein 8 (RBBP8)

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CTIP; RIM; SAE2; CTBP-Interacting Protein; Retinoblastoma-interacting protein and myosin-like; Sporulation in the absence of SPO11 protein 2 homolog

Retinoblastoma Binding Protein 8 (RBBP8)
CCC F771
HGNC 9891
MGI 2442995
PubMed 23353824
RGD 1308872
UniProt Q99708
Wiki RBBP8
Retinoblastoma-binding protein 8 is is a ubiquitously expressed nuclear protein. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation.
This protein complexes with transcriptional co-repressor CTBP. It is also associated with BRCA1 and is thought to modulate the functions of BRCA1 in transcriptional regulation, DNA repair, and/or cell cycle checkpoint control. It is suggested that this gene may itself be a tumor suppressor acting in the same pathway as BRCA1. Three transcript variants encoding two different isoforms have been found for this gene. More transcript variants exist, but their full-length natures have not been determined.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 8 (RBBP8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 8 (RBBP8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 8 (RBBP8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 8 (RBBP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 8 (RBBP8) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 8 (RBBP8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 8 (RBBP8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 8 (RBBP8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 8 (RBBP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 8 (RBBP8) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 8 (RBBP8) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 8 (RBBP8) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 8 (RBBP8) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 8 (RBBP8) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 8 (RBBP8) ELISA Kit Customized Service Offer
  1. "Molecular cloning and characterization of a novel retinoblastoma-binding protein."Genomics 51:351-358(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Interaction between a cellular protein that binds to the C-terminal region of adenovirus E1A (CtBP) and a novel cellular protein is disrupted by E1A through a conserved PLDLS motif."J. Biol. Chem. 273:8549-8552(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "DNA sequence and analysis of human chromosome 18." Nature 437:551-555(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Nuclear localization and cell cycle-specific expression of CtIP, a protein that associates with the BRCA1 tumor suppressor."J. Biol. Chem. 275:18541-18549(2000) [PubMed] [Europe PMC] [Abstract]
  8. "Functional link of BRCA1 and ataxia telangiectasia gene product in DNA damage response."Nature 406:210-215(2000) [PubMed] [Europe PMC] [Abstract]
  9. "The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity."J. Biol. Chem. 277:7849-7856(2002) [PubMed] [Europe PMC] [Abstract]
  10. "SIAH-1 interacts with CtIP and promotes its degradation by the proteasome pathway."Oncogene 22:8845-8851(2003) [PubMed] [Europe PMC] [Abstract]
  11. "Dimerization of CtIP, a BRCA1- and CtBP-interacting protein, is mediated by an N-terminal coiled-coil motif."J. Biol. Chem. 279:26932-26938(2004) [PubMed] [Europe PMC] [Abstract]
  12. "DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains."Mol. Cell. Biol. 24:9478-9486(2004) [PubMed] [Europe PMC] [Abstract]
  13. "BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP."Genes Dev. 20:1721-1726(2006) [PubMed] [Europe PMC] [Abstract]
  14. "CtIP activates its own and cyclin D1 promoters via the E2F/RB pathway during G1/S progression."Mol. Cell. Biol. 26:3124-3134(2006) [PubMed] [Europe PMC] [Abstract]
  15. "Human CtIP promotes DNA end resection."Nature 450:509-514(2007) [PubMed] [Europe PMC] [Abstract]
  16. "Functional complementation studies identify candidate genes and common genetic variants associated with ovarian cancer survival."Hum. Mol. Genet. 18:1869-1878(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Human CtIP mediates cell cycle control of DNA end resection and double strand break repair."J. Biol. Chem. 284:9558-9565(2009) [PubMed] [Europe PMC] [Abstract]
  18. "N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair."J. Biol. Chem. 284:31746-31752(2009) [PubMed] [Europe PMC] [Abstract]
  19. "CtIP links DNA double-strand break sensing to resection."Mol. Cell 36:954-969(2009) [PubMed] [Europe PMC] [Abstract]
  20. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  22. "Human SIRT6 promotes DNA end resection through CtIP deacetylation."Science 329:1348-1353(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Modification of BRCA1-associated breast and ovarian cancer risk by BRCA1-interacting genes." Cancer Res. 71:5792-5805(2011) [PubMed] [Europe PMC] [Abstract]
  24. "CtIP mutations cause Seckel and Jawad syndromes."PLoS Genet. 7:E1002310-E1002310(2011) [PubMed] [Europe PMC] [Abstract]