Retinoblastoma Binding Protein 7 (RBBP7)

[Edit]

RbAp46; Histone Acetyltransferase Type B Subunit 2; Retinoblastoma-Binding Protein p46; Nucleosome-remodeling factor subunit RBAP46

Retinoblastoma Binding Protein 7 (RBBP7)
RBBP7 is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.The predicted 425-amino acid human RBBP7 protein is identical to mouse Rbbp7, except for 1 conserved amino acid substitution, and is 89% identical to human RBBP4. RBBP7 contains internal trp-asp (WD) repeats which are conserved with those of RBBP4.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 7 (RBBP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 7 (RBBP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 7 (RBBP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 7 (RBBP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 7 (RBBP7) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 7 (RBBP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 7 (RBBP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 7 (RBBP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 7 (RBBP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 7 (RBBP7) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 7 (RBBP7) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 7 (RBBP7) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 7 (RBBP7) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 7 (RBBP7) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 7 (RBBP7) ELISA Kit Customized Service Offer
  1. "Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast."J. Biol. Chem. 270:25507-25513(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence of the human X chromosome." Nature 434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex."Cell 89:357-364(1997) [PubMed] [Europe PMC] [Abstract]
  5. "The dermatomyositis-specific autoantigen Mi2 is a component of a complex containing histone deacetylase and nucleosome remodeling activities."Cell 95:279-289(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Nucleosomal DNA regulates the core-histone-binding subunit of the human Hat1 acetyltransferase."Curr. Biol. 8:96-108(1998) [PubMed] [Europe PMC] [Abstract]
  7. "SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex."Mol. Cell 1:1021-1031(1998) [PubMed] [Europe PMC] [Abstract]
  8. "Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation."Genes Dev. 13:1924-1935(1999) [PubMed] [Europe PMC] [Abstract]
  9. "BRCA1 interacts with components of the histone deacetylase complex."Proc. Natl. Acad. Sci. U.S.A. 96:4983-4988(1999) [PubMed] [Europe PMC] [Abstract]
  10. "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and phosphorylated CREB."Mol. Cell. Biol. 20:4970-4978(2000) [PubMed] [Europe PMC] [Abstract]
  11. "Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1."J. Biol. Chem. 276:6817-6824(2001) [PubMed] [Europe PMC] [Abstract]
  12. "Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex."J. Biol. Chem. 276:8734-8739(2001) [PubMed] [Europe PMC] [Abstract]
  13. "Histone methyltransferase activity associated with a human multiprotein complex containing the Enhancer of Zeste protein."Genes Dev. 16:2893-2905(2002) [PubMed] [Europe PMC] [Abstract]
  14. "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)."Mol. Cell. Biol. 22:835-848(2002) [PubMed] [Europe PMC] [Abstract]
  15. "Isolation of human NURF: a regulator of Engrailed gene expression."EMBO J. 22:6089-6100(2003) [PubMed] [Europe PMC] [Abstract]
  16. "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity."J. Biol. Chem. 278:42560-42568(2003) [PubMed] [Europe PMC] [Abstract]
  17. "MBD3L1 is a transcriptional repressor that interacts with methyl-CpG-binding protein 2 (MBD2) and components of the NuRD complex."J. Biol. Chem. 279:52456-52464(2004) [PubMed] [Europe PMC] [Abstract]
  18. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  19. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  20. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  21. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  22. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  23. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  24. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  25. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  26. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  27. "Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46."Structure 16:1077-1085(2008) [PubMed] [Europe PMC] [Abstract]