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Retinoblastoma Binding Protein 6 (RBBP6)

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P2P-R; RBQ-1; PACT; SNAMA; Proliferation Potential-Related Protein; Retinoblastoma-binding Q protein 1; p53-associated cellular protein of testis

Retinoblastoma Binding Protein 6 (RBBP6)
CCC F769
HGNC 9889
MGI 894835
PubMed 23536819
UniProt Q7Z6E9
Wiki RBBP6
The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins.Cell cycle-dependent phosphorylation regulates the activity of pRB. Mather et al. (2005) stated that the RBBP6 protein reported by Sakai et al. (1995) is a truncated homolog of Drosophila Snama. They reported that there are 2 human RBBP6 transcripts: a short form encoding a 118-amino acid protein, and a long form encoding a 1,792-amino acid protein. The long protein contains an N-terminal ubiquitin-like domain, which Mather et al. (2005) called a DWNN (domain with no name) domain, followed by a CCHC zinc finger motif, a cysteine-rich RING finger-like motif, and 2 C-terminal lysine-rich regions. The DWNN domain is highly conserved through eukaryotes, but is absent in prokaryotes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 6 (RBBP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 6 (RBBP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 6 (RBBP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 6 (RBBP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 6 (RBBP6) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Retinoblastoma Binding Protein 6 (RBBP6) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Retinoblastoma Binding Protein 6 (RBBP6) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Retinoblastoma Binding Protein 6 (RBBP6) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Retinoblastoma Binding Protein 6 (RBBP6) CLIA Kit Customized Service Offer
n/a ELISA Kit for Retinoblastoma Binding Protein 6 (RBBP6) ELISA Kit Customized Service Offer
  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  2. "cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product."Genomics 30:98-101(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity."J. Cell. Physiol. 191:145-154(2002) [PubMed] [Europe PMC] [Abstract]
  6. ErratumJ. Cell. Physiol. 192:359-360(2002)
  7. "Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis."Clin. Cancer Res. 10:6437-6448(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  9. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  10. "PACT is a negative regulator of p53 and essential for cell growth and embryonic development."Proc. Natl. Acad. Sci. U.S.A. 104:7951-7956(2007) [PubMed] [Europe PMC] [Abstract]
  11. "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."Science 316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
  12. "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1."J. Mol. Biol. 384:908-916(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  14. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  15. "Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography."Proteomics 8:1346-1361(2008) [PubMed] [Europe PMC] [Abstract]
  16. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  17. "Characterization of hNek6 interactome reveals an important role for its short N-terminal domain and colocalization with proteins at the centrosome."J. Proteome Res. 9:6298-6316(2010) [PubMed] [Europe PMC] [Abstract]
  18. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  19. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  20. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  21. "DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways."BMC Struct. Biol. 6:1-1(2006) [PubMed] [Europe PMC] [Abstract]
  22. "Solution structure of the zinc finger CCHC domain and of the RING finger from the human retinoblastoma-binding protein 6 (retinoblastoma-binding Q protein 1, RBQ-1)."Submitted (APR-2008) to the PDB data bank