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Phosphorylase Kinase Beta (PHKb)

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Phosphorylase Kinase Beta (PHKb)
CCC F762
HGNC 8927
MGI 97578
PubMed 10487978
RGD 620186
UniProt Q93100
Wiki PHKB
Phosphorylase kinase is a polymer of 16 subunits, four each of alpha, beta, gamma and delta. The alpha subunit includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The beta subunit is the same in both the muscle and hepatic isoforms, encoded by PHKb, which is a member of the phosphorylase b kinase regulatory subunit family. The gamma subunit also includes the skeletal muscle and hepatic isoforms, encoded by two different genes. The delta subunit is a calmodulin and can be encoded by three different genes. The gamma subunits contain the active site of the enzyme, whereas the alpha and beta subunits have regulatory functions controlled by phosphorylation. The delta subunit mediates the dependence of the enzyme on calcium concentration.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphorylase Kinase Beta (PHKb) Recombinant Protein Customized Service Offer
Antibodies PAF762Hu01 Polyclonal Antibody to Phosphorylase Kinase Beta (PHKb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phosphorylase Kinase Beta (PHKb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphorylase Kinase Beta (PHKb) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphorylase Kinase Beta (PHKb) Recombinant Protein Customized Service Offer
Antibodies PAF762Mu01 Polyclonal Antibody to Phosphorylase Kinase Beta (PHKb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phosphorylase Kinase Beta (PHKb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphorylase Kinase Beta (PHKb) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphorylase Kinase Beta (PHKb) Recombinant Protein Customized Service Offer
Antibodies PAF762Ra01 Polyclonal Antibody to Phosphorylase Kinase Beta (PHKb) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phosphorylase Kinase Beta (PHKb) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphorylase Kinase Beta (PHKb) ELISA Kit Customized Service Offer
  1. "Structure of the human gene encoding the phosphorylase kinase beta subunit (PHKB)."Eur. J. Biochem. 238:374-380(1996) [PubMed] [Europe PMC] [Abstract]
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  3. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  10. "Autosomal recessive phosphorylase kinase deficiency in liver, caused by mutations in the gene encoding the beta subunit (PHKB)."Am. J. Hum. Genet. 61:539-546(1997) [PubMed] [Europe PMC] [Abstract]
  11. "Phosphorylase-kinase-deficient liver glycogenosis with an unusual biochemical phenotype in blood cells associated with a missense mutation in the beta subunit gene (PHKB)."Hum. Genet. 101:170-174(1997) [PubMed] [Europe PMC] [Abstract]
  12. "Muscle glycogenosis with low phosphorylase kinase activity: mutations in PHKA1, PHKG1 or six other candidate genes explain only a minority of cases."Eur. J. Hum. Genet. 11:516-526(2003) [PubMed] [Europe PMC] [Abstract]
  13. "The consensus coding sequences of human breast and colorectal cancers." Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]