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Phosducin Like Protein 3 (PDCL3)

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VIAF; VIAF1; HTPHLP; PhPL3; Viral IAP-associated factor 1

Phosducin Like Protein 3 (PDCL3)
CCC F758
HGNC 28860
MGI 1916083
PubMed 23792958
RGD 1309663
UniProt Q9H2J4
VIAF overexpression did not alter the ability of Op-IAP to prevent BAX-mediated apoptosis. However, suppression of VIAF by RNA interference in human embryonic kidney cells inhibited processing of caspase-3 (CASP3) following induction of the apoptotic program by BAX. VIAF was a substrate for Op-IAP-mediated ubiquitination, suggesting that VIAF may be regulated by IAP proteins in a ubiquitination-dependent manner. Inhibitor of apoptosis proteins (IAPs) are involved in suppression of apoptosis, signal transduction, cell cycle control, and gene regulation. The deduced 239-amino acid protein has a calculated molecular mass of 28 kD. Northern blot analysis detected variable expression of a 1.2-kb transcript in all tissues examined. Epitope-tagged and endogenous VIAF showed cytoplasmic expression.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosducin Like Protein 3 (PDCL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosducin Like Protein 3 (PDCL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosducin Like Protein 3 (PDCL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosducin Like Protein 3 (PDCL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosducin Like Protein 3 (PDCL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosducin Like Protein 3 (PDCL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosducin Like Protein 3 (PDCL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosducin Like Protein 3 (PDCL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosducin Like Protein 3 (PDCL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosducin Like Protein 3 (PDCL3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosducin Like Protein 3 (PDCL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosducin Like Protein 3 (PDCL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosducin Like Protein 3 (PDCL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosducin Like Protein 3 (PDCL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosducin Like Protein 3 (PDCL3) ELISA Kit Customized Service Offer
  1. "VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation."J. Biol. Chem. 279:51091-51099(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Identification of PDCL3 as a novel chaperone protein involved in the generation of functional VEGF receptor 2."J. Biol. Chem. 288:23171-23181(2013) [PubMed] [Europe PMC] [Abstract]