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Peroxisomal Biogenesis Factor 11 Beta (PEX11b)

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PEX11-beta; Protein PEX11 homolog beta; Peroxisomal biogenesis factor 11B; Peroxin-11B

Peroxisomal Biogenesis Factor 11 Beta (PEX11b)
CCC F737
HGNC 8853
MGI 1338882
PubMed 16218949
RGD 1310353
UniProt O96011
Wiki PEX11B
The closest relative of the encoded human protein was the product of a second human gene; the authors designated the 2 human genes PEX11-alpha and PEX11-beta.
The deduced 259-amino acid PEX11-beta protein shares approximately 20% amino acid identity with yeast Pex11. PEX11-beta has 2 predicted membrane-spanning domains, 1 at its C terminus and a second located approximately 100 amino acids from its N terminus. The termini of PEX11-beta are predicted to extend into the cytoplasm. Localization studies indicated that PEX11-beta is a peroxisomal protein. Northern blot analysis of rat tissues showed that Pex11-beta mRNA levels were similar in all tissues examined and were unaffected by peroxisome-proliferating agents.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxisomal Biogenesis Factor 11 Beta (PEX11b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal Biogenesis Factor 11 Beta (PEX11b) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxisomal Biogenesis Factor 11 Beta (PEX11b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal Biogenesis Factor 11 Beta (PEX11b) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Peroxisomal Biogenesis Factor 11 Beta (PEX11b) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Peroxisomal Biogenesis Factor 11 Beta (PEX11b) CLIA Kit Customized Service Offer
n/a ELISA Kit for Peroxisomal Biogenesis Factor 11 Beta (PEX11b) ELISA Kit Customized Service Offer
  1. "cDNA cloning and characterization of a constitutively expressed isoform of the human peroxin Pex11p."Biochem. Biophys. Res. Commun. 252:529-533(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Expression of PEX11beta mediates peroxisome proliferation in the absence of extracellular stimuli."J. Biol. Chem. 273:29607-29614(1998) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis."J. Cell Biol. 148:931-944(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11."J. Biol. Chem. 278:17012-17020(2003) [PubMed] [Europe PMC] [Abstract]
  8. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "A novel defect of peroxisome division due to a homozygous non-sense mutation in the PEX11beta gene."J. Med. Genet. 49:307-313(2012) [PubMed] [Europe PMC] [Abstract]