Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2)

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PACS1L; PACS1-like protein

Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2)
PACS2. The deduced 889-amino acid protein shares 54% identity with PACS1 overall, and 81% identity in the 140-amino acid cargo/adaptor-binding region. Northern blot analysis detected broad expression of a 3.8-kb PACS2 transcript, with highest expression in skeletal muscle, followed by heart, brain, pancreas, and testis. Confocal immunofluorescence of a mouse rhabdomyosarcoma cell line showed Pacs2 colocalized with an endoplasmic reticulum (ER) marker.
Pacs2 also controlled ER homeostasis and formation of ER lipid synthesizing centers that are found on mitochondria-associated membranes. In response to apoptotic inducers, Pacs2 translocated full-length Bid to mitochondria, which initiates a sequence of events including Bid truncation, release of cytochrome c, and activation of Casp3, leading to cell death.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF706Mu01 Recombinant Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF706Mu01 Polyclonal Antibody to Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphofurin Acidic Cluster Sorting Protein 2 (PACS2) ELISA Kit Customized Service Offer
  1. "PACS-2 controls endoplasmic reticulum-mitochondria communication and Bid-mediated apoptosis."EMBO J. 24:717-729(2005) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Trafficking of TRPP2 by PACS proteins represents a novel mechanism of ion channel regulation."EMBO J. 24:705-716(2005) [PubMed] [Europe PMC] [Abstract]
  6. "HIV-1 Nef binds PACS-2 to assemble a multikinase cascade that triggers major histocompatibility complex class I (MHC-I) down-regulation: analysis using short interfering RNA and knock-out mice."J. Biol. Chem. 283:11772-11784(2008) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]