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Nucleolar Protein 3 (NOL3)

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MYC; ARC; NOP; NOP30; Apoptosis Repressor With CARD Domain; Muscle-enriched cytoplasmic protein; Nucleolar protein of 30 kDa

Nucleolar Protein 3 (NOL3)
CCC F675
HGNC 7869
MGI 1925938
PubMed 22926851
RGD 708558
UniProt O60936
Wiki NOL3
Sequence analysis of the 219-amino acid NOP30 protein predicted that it contains a highly acidic N terminus and a basic C terminus enriched with arginines, serines, and prolines and having multiple phosphorylation sites. In contrast, SFRS9 is relatively strongly and ubiquitously expressed as a 1.35-kb transcript. In situ hybridization analysis showed that NOP30 is expressed in the pia mater, a tissue surrounding the brain containing blood vessels lined with smooth muscle cells. Binding analysis indicated that NOP30 binds to itself and that the N and C termini of NOP30 interact with SFRS9 through its RS domain. Confocal microscopy demonstrated that NOP30, through its arginine-rich C terminus, colocalizes with B23 (NPM1) in the granular component of nucleoli; however, the majority of NOP30 was localized in the fibrillar component.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 3 (NOL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 3 (NOL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 3 (NOL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 3 (NOL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 3 (NOL3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF675Mu01 Recombinant Nucleolar Protein 3 (NOL3) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF675Mu01 Polyclonal Antibody to Nucleolar Protein 3 (NOL3) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Nucleolar Protein 3 (NOL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 3 (NOL3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Nucleolar Protein 3 (NOL3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Nucleolar Protein 3 (NOL3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Nucleolar Protein 3 (NOL3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Nucleolar Protein 3 (NOL3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Nucleolar Protein 3 (NOL3) ELISA Kit Customized Service Offer
  1. "ARC, an inhibitor of apoptosis expressed in skeletal muscle and heart that interacts selectively with caspases."Proc. Natl. Acad. Sci. U.S.A. 95:5156-5160(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Alternative splicing determines the intracellular localization of the novel nuclear protein Nop30 and its interaction with the splicing factor SRp30c."J. Biol. Chem. 274:10951-10962(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The sequence and analysis of duplication-rich human chromosome 16." Nature 432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Apoptosis repressor with caspase recruitment domain protects against cell death by interfering with Bax activation."J. Biol. Chem. 279:21233-21238(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Calcium binding of ARC mediates regulation of caspase 8 and cell death."Mol. Cell. Biol. 24:9763-9770(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress."Circulation 113:1203-1212(2006) [PubMed] [Europe PMC] [Abstract]
  9. "The apoptosis inhibitor ARC undergoes ubiquitin-proteasomal-mediated degradation in response to death stimuli: identification of a degradation-resistant mutant."J. Biol. Chem. 282:5522-5528(2007) [PubMed] [Europe PMC] [Abstract]
  10. "Familial cortical myoclonus with a mutation in NOL3."Ann. Neurol. 72:175-183(2012) [PubMed] [Europe PMC] [Abstract]
  11. "Screening of mutations in NOL3 in a myoclonic syndromes series."J. Neurol. 261:1830-1831(2014) [PubMed] [Europe PMC] [Abstract]