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Phosphodiesterase 12 (PDE12)

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2'-PDE; 2'-Phosphodiesterase; Mitochondrial deadenylase

Phosphodiesterase 12 (PDE12)
CCC F658
HGNC 25386
MGI 2443226
PubMed 21666256
RGD 1310975
UniProt Q6L8Q7
Phosphodiesterase 12 belongs to the CCR4/nocturin family. Enzyme that cleaves 2',5'-phosphodiester bond linking adenosines of the 5'-triphosphorylated oligoadenylates, triphosphorylated oligoadenylates referred as 2-5A modulates the 2-5A system.
This enzyme degraded triphosphorylated 2-5A to produce AMP and ATP. Also cleaves 3',5'-phosphodiester bond of oligoadenylates. Play a role as a negative regulator of the The 2-5A system that is one of the major pathways for antiviral and antitumor functions induced by interferons (IFNs). Suppression of this enzyme induces reduction of viral replication in Hela cells, thus counteracting the antiviral pathway probably by inhibiting the 2-5A system.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 12 (PDE12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 12 (PDE12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 12 (PDE12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 12 (PDE12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 12 (PDE12) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF658Mu01 Recombinant Phosphodiesterase 12 (PDE12) Positive Control; Immunogen; SDS-PAGE; WB.
RPF658Mu02 Recombinant Phosphodiesterase 12 (PDE12) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF658Mu01 Polyclonal Antibody to Phosphodiesterase 12 (PDE12) WB; IHC; ICC; IP.
PAF658Mu02 Polyclonal Antibody to Phosphodiesterase 12 (PDE12) WB; IHC; ICC; IP.
Assay Kits SEF658Mu ELISA Kit for Phosphodiesterase 12 (PDE12) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 12 (PDE12) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 12 (PDE12) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 12 (PDE12) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 12 (PDE12) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 12 (PDE12) ELISA Kit Customized Service Offer
  1. "Identification of 2'-phosphodiesterase, which plays a role in the 2-5A system regulated by interferon."J. Biol. Chem. 279:37832-37841(2004) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  5. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  7. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Human 2'-phosphodiesterase localizes to the mitochondrial matrix with a putative function in mitochondrial RNA turnover."Nucleic Acids Res. 39:3754-3770(2011) [PubMed] [Europe PMC] [Abstract]
  9. "PDE12 removes mitochondrial RNA poly(A) tails and controls translation in human mitochondria."Nucleic Acids Res. 39:7750-7763(2011) [PubMed] [Europe PMC] [Abstract]
  10. "Characterization of human phosphodiesterase 12 and identification of a novel 2'-5' oligoadenylate nuclease - The ectonucleotide pyrophosphatase/phosphodiesterase 1."Biochimie 94:1098-1107(2012) [PubMed] [Europe PMC] [Abstract]