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Phosphodiesterase 11A (PDE11A)

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cAMP and cGMP phosphodiesterase 11A; Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A

Phosphodiesterase 11A (PDE11A)
CCC F657
HGNC 8773
MGI 3036251
PubMed 20920776
RGD 621793
UniProt Q9HCR9
Wiki PDE11A
The PDE11A cDNA encodes a 490-amino acid enzyme that is most similar to human PDE5, especially across the catalytic domain, where the 2 proteins share 50% sequence identity.
The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 11A (PDE11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 11A (PDE11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 11A (PDE11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 11A (PDE11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 11A (PDE11A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 11A (PDE11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 11A (PDE11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 11A (PDE11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 11A (PDE11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 11A (PDE11A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 11A (PDE11A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 11A (PDE11A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 11A (PDE11A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 11A (PDE11A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 11A (PDE11A) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of two novel phosphodiesterase PDE11A variants showing unique structure and tissue-specific expression."J. Biol. Chem. 275:31469-31479(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Molecular cloning and characterization of a distinct human phosphodiesterase gene family: PDE11A."Proc. Natl. Acad. Sci. U.S.A. 97:3702-3707(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Cloning and characterisation of two splice variants of human phosphodiesterase 11A."Proc. Natl. Acad. Sci. U.S.A. 97:12891-12895(2000) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic organization of the human phosphodiesterase PDE11A gene: evolutionary relatedness with other PDEs containing GAF domains."Eur. J. Biochem. 268:168-178(2001) [PubMed] [Europe PMC] [Abstract]
  5. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "3',5'-cyclic nucleotide phosphodiesterase 11A: localization in human tissues."Int. J. Impot. Res. 17:320-325(2005) [PubMed] [Europe PMC] [Abstract]
  8. "Phosphodiesterase 11 (PDE11): is it a player in human testicular function?"Int. J. Impot. Res. 17:467-468(2005) [PubMed] [Europe PMC] [Abstract]
  9. "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11."J. Biol. Chem. 281:2841-2846(2006) [PubMed] [Europe PMC] [Abstract]
  10. "A genome-wide scan identifies mutations in the gene encoding phosphodiesterase 11A4 (PDE11A) in individuals with adrenocortical hyperplasia." Nat. Genet. 38:794-800(2006) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]