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Phosphodiesterase 10A (PDE10A)

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cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Phosphodiesterase 10A (PDE10A)
CCC F656
HGNC 8772
MGI 1345143
PubMed 21355834
RGD 68434
UniProt Q9Y233
Wiki PDE10A
Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE10A, eliminate cAMP- and cGMP-mediated intracellular signaling by hydrolyzing the cyclic nucleotide to the corresponding nucleoside 5-prime monophosphate.
The deduced 779-amino acid protein has a calculated molecular mass of 88.4 kD and contains cGMP-binding sequences and a catalytic domain. Northern blot analysis detected a 10-kb PDE10A transcript in several tissues, with highest levels in fetal brain and kidney, in putamen and caudate nucleus of adult brain, and in thyroid and testis. A 4-kb transcript was also detected in thyroid and testis. mRNA dot blot analysis showed a similar PDE10A expression pattern.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF656Hu01 Recombinant Phosphodiesterase 10A (PDE10A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF656Hu01 Polyclonal Antibody to Phosphodiesterase 10A (PDE10A) WB; IHC; ICC; IP.
MAF656Hu21 Monoclonal Antibody to Phosphodiesterase 10A (PDE10A) WB; IHC; ICC; IP.
Assay Kits SEF656Hu ELISA Kit for Phosphodiesterase 10A (PDE10A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 10A (PDE10A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 10A (PDE10A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 10A (PDE10A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 10A (PDE10A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 10A (PDE10A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 10A (PDE10A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 10A (PDE10A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 10A (PDE10A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 10A (PDE10A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 10A (PDE10A) ELISA Kit Customized Service Offer
  1. "Characterization and phosphorylation of PDE10A2, a novel alternative splice variant of human phosphodiesterase that hydrolyzes cAMP and cGMP."Biochem. Biophys. Res. Commun. 261:551-557(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Cloning and characterization of a novel human phosphodiesterase that hydrolyzes both cAMP and cGMP (PDE10A)."J. Biol. Chem. 274:18438-18445(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Isolation and characterization of PDE10A, a novel human 3',5'-cyclic nucleotide phosphodiesterase."Gene 234:109-117(1999) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 6." Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The human phosphodiesterase PDE10A gene genomic organization and evolutionary relatedness with other PDEs containing GAF domains."Eur. J. Biochem. 267:5943-5951(2000) [PubMed] [Europe PMC] [Abstract]
  7. "cAMP is a ligand for the tandem GAF domain of human phosphodiesterase 10 and cGMP for the tandem GAF domain of phosphodiesterase 11."J. Biol. Chem. 281:2841-2846(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Structural insight into substrate specificity of phosphodiesterase 10."Proc. Natl. Acad. Sci. U.S.A. 104:5782-5787(2007) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of the GAF-B domain from human phosphodiesterase 10A complexed with its ligand, cAMP."J. Biol. Chem. 283:19657-19664(2008) [PubMed] [Europe PMC] [Abstract]