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Phosphodiesterase 6C, cGMP Specific (PDE6C)

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PDEA2; Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'

Phosphodiesterase 6C, cGMP Specific (PDE6C)
CCC F648
HGNC 8787
MGI 105956
PubMed 19615668
RGD 1309844
UniProt P51160
Wiki PDE6C
In the retinal rods, phosphodiesterase (PDE) is composed of an 88-kD alpha subunit, an 84-kD beta subunit and two 11-kD gamma subunits, while in cones PDE occurs as a homodimer of two 94-kD alpha-prime subunits (PDE6C) that are associated with 3 smaller proteins of 11, 13, and 15 kD. The 11- and 13-kD proteins are similar to the rod gamma subunits, while the 15-kD delta subunit binds to both cone and rod PDE.
It was found to be 3,455 bp in length and to encode a polypeptide of 858 amino acids and a calculated molecular mass of 99,169 Da. The deduced amino acid sequence displayed high homology to the alpha, beta, and alpha-prime subunits of bovine, human, chicken, and mouse photoreceptor PDEs.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 6C, cGMP Specific (PDE6C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 6C, cGMP Specific (PDE6C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 6C, cGMP Specific (PDE6C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 6C, cGMP Specific (PDE6C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 6C, cGMP Specific (PDE6C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 6C, cGMP Specific (PDE6C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 6C, cGMP Specific (PDE6C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 6C, cGMP Specific (PDE6C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 6C, cGMP Specific (PDE6C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 6C, cGMP Specific (PDE6C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 6C, cGMP Specific (PDE6C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 6C, cGMP Specific (PDE6C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 6C, cGMP Specific (PDE6C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 6C, cGMP Specific (PDE6C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 6C, cGMP Specific (PDE6C) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of a cDNA encoding the alpha' subunit of human cone cGMP-phosphodiesterase."Gene 166:205-211(1995) [PubMed] [Europe PMC] [Abstract]
  2. "Gene structure and amino acid sequence of the human cone photoreceptor cGMP-phosphodiesterase alpha' subunit (PDEA2) and its chromosomal localization to 10q24."Genomics 28:429-435(1995) [PubMed] [Europe PMC] [Abstract]
  3. "Human cone-specific cGMP phosphodiesterase alpha' subunit: complete cDNA sequence and gene arrangement."FEBS Lett. 381:149-152(1996) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Screening of the gene encoding the alpha'-subunit of cone cGMP-PDE in patients with retinal degenerations."Invest. Ophthalmol. Vis. Sci. 40:1818-1822(1999) [PubMed] [Europe PMC] [Abstract]
  6. "Homozygosity mapping reveals PDE6C mutations in patients with early-onset cone photoreceptor disorders."Am. J. Hum. Genet. 85:240-247(2009) [PubMed] [Europe PMC] [Abstract]
  7. "Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma." Nature 469:539-542(2011) [PubMed] [Europe PMC] [Abstract]