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Phosphodiesterase 4B, cAMP Specific (PDE4B)

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DPDE4; PDE32; Dunce(Drosophila)Homolog Phosphodiesterase E4; cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Phosphodiesterase 4B, cAMP Specific (PDE4B)
CCC F642
HGNC 8781
MGI 99557
PubMed 16293762
RGD 1599565
UniProt Q07343
Wiki PDE4B
PDE4B is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. Cyclic nucleotides are important second messengers that regulate and mediate a number of cellular responses to extracellular signals, such as hormones, light, and neurotransmitters. The cyclic nucleotide phosphodiesterases (PDEs) regulate the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction.
This gene encodes a protein that specifically hydrolyzes cAMP. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF642Hu01 Recombinant Phosphodiesterase 4B, cAMP Specific (PDE4B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 4B, cAMP Specific (PDE4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 4B, cAMP Specific (PDE4B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 4B, cAMP Specific (PDE4B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 4B, cAMP Specific (PDE4B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 4B, cAMP Specific (PDE4B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF642Ra01 Recombinant Phosphodiesterase 4B, cAMP Specific (PDE4B) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF642Ra01 Polyclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) WB; IHC
MAF642Ra21 Monoclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) WB; IHC; ICC; IP.
MAF642Ra24 Monoclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) WB; IHC; ICC; IP.
MAF642Ra23 Monoclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) WB; IHC; ICC; IP.
MAF642Ra25 Monoclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) WB; IHC; ICC; IP.
MAF642Ra22 Monoclonal Antibody to Phosphodiesterase 4B, cAMP Specific (PDE4B) WB; IHC; ICC; IP.
Assay Kits SEF642Ra ELISA Kit for Phosphodiesterase 4B, cAMP Specific (PDE4B) Enzyme-linked immunosorbent assay for Antigen Detection.
  1. "The cDNA of a human lymphocyte cyclic-AMP phosphodiesterase (PDE IV) reveals a multigene family."Gene 129:239-247(1993) [PubMed] [Europe PMC] [Abstract]
  2. "A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs."Mol. Cell. Biol. 13:6558-6571(1993) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and transient expression in COS7 cells of a novel human PDE4B cAMP-specific phosphodiesterase, HSPDE4B3."Biochem. J. 328:549-558(1997) [PubMed] [Europe PMC] [Abstract]
  4. "A low-Km, rolipram-sensitive, cAMP-specific phosphodiesterase from human brain. Cloning and expression of cDNA, biochemical characterization of recombinant protein, and tissue distribution of mRNA."J. Biol. Chem. 268:6470-6476(1993) [PubMed] [Europe PMC] [Abstract]
  5. "PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6)."J. Pharmacol. Exp. Ther. 322:600-609(2007) [PubMed] [Europe PMC] [Abstract]
  6. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Atomic structure of PDE4: insights into phosphodiesterase mechanism and specificity."Science 288:1822-1825(2000) [PubMed] [Europe PMC] [Abstract]
  10. "Crystal structures of the catalytic domain of phosphodiesterase 4B complexed with AMP, 8-Br-AMP, and rolipram."J. Mol. Biol. 337:355-365(2004) [PubMed] [Europe PMC] [Abstract]
  11. "A glutamine switch mechanism for nucleotide selectivity by phosphodiesterases."Mol. Cell 15:279-286(2004) [PubMed] [Europe PMC] [Abstract]
  12. "Structural basis for the activity of drugs that inhibit phosphodiesterases."Structure 12:2233-2247(2004) [PubMed] [Europe PMC] [Abstract]
  13. "A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design."Nat. Biotechnol. 23:201-207(2005) [PubMed] [Europe PMC] [Abstract]
  14. "Structures of the four subfamilies of phosphodiesterase-4 provide insight into the selectivity of their inhibitors."Biochem. J. 408:193-201(2007) [PubMed] [Europe PMC] [Abstract]
  15. "Pyrazolopyridines as a novel structural class of potent and selective PDE4 inhibitors."Bioorg. Med. Chem. Lett. 18:4237-4241(2008) [PubMed] [Europe PMC] [Abstract]