≡

Phosphodiesterase 3B, cGMP Inhibited (PDE3B)

[Edit]

HcGIP1; CGIP1; CGIPDE1; Cyclic GMP-inhibited phosphodiesterase B; cGMP-inhibited 3',5'-cyclic phosphodiesterase B

Phosphodiesterase 3B, cGMP Inhibited (PDE3B)
CCC F640
HGNC 8779
MGI 1333863
PubMed 10480615
RGD 61943
UniProt Q13370
Wiki PDE3
Cyclic nucleotide phosphodiesterases (PDEs) are a superfamily of related enzymes involved in many regulatory pathways. The PDE3 family is characterized by high affinity for cAMP, inhibition by cGMP, sensitivity to specific inhibitors such as cilostamide and milrinone, and by phosphorylation and activation in response to insulin and agents that increase cAMP.
This coding sequence predicts a protein of 1,112 amino acids with 81% amino acid identity with rat PDE3B. Northern blot analysis showed low levels of PDE3B expression in liver, spleen, lung, and kidney, and abundant 5.4- and 6.4-kb transcripts in adipose tissue from several locations. Lobbert et al. (1996) also isolated cDNAs of human PDE3B and reported similar findings.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 3B, cGMP Inhibited (PDE3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 3B, cGMP Inhibited (PDE3B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 3B, cGMP Inhibited (PDE3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 3B, cGMP Inhibited (PDE3B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 3B, cGMP Inhibited (PDE3B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 3B, cGMP Inhibited (PDE3B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 3B, cGMP Inhibited (PDE3B) ELISA Kit Customized Service Offer
  1. "Characterization of the cDNA and gene encoding human PDE3B, the cGIP1 isoform of the human cyclic GMP-inhibited cyclic nucleotide phosphodiesterase family."Genomics 36:476-485(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Differential expression of cGMP-inhibited cyclic nucleotide phosphodiesterases in human hepatoma cell lines."FEBS Lett. 390:29-33(1996) [PubMed] [Europe PMC] [Abstract]
  3. "Molecular cloning and chromosomal assignment of the human homologue of the rat cGMP-inhibited phosphodiesterase 1 (PDE3A) -- a gene involved in fat metabolism located at 11p15.1."Genomics 37:211-218(1996) [PubMed] [Europe PMC] [Abstract]
  4. "Importance of cAMP-response element-binding protein in regulation of expression of the murine cyclic nucleotide phosphodiesterase 3B (Pde3b) gene in differentiating 3T3-L1 preadipocytes."J. Biol. Chem. 281:21096-21113(2006) [PubMed] [Europe PMC] [Abstract]
  5. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  7. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  8. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A phosphodiesterase 3B-based signaling complex integrates exchange protein activated by cAMP 1 and phosphatidylinositol 3-kinase signals in human arterial endothelial cells."J. Biol. Chem. 286:16285-16296(2011) [PubMed] [Europe PMC] [Abstract]
  10. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  11. "Crystal structure of human phosphodiesterase 3B: atomic basis for substrate and inhibitor specificity."Biochemistry 43:6091-6100(2004) [PubMed] [Europe PMC] [Abstract]