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Phosphodiesterase 2A, cGMP Stimulated (PDE2A)

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cGSPDE; CGS-PDE; Cyclic GMP-stimulated phosphodiesterase; cGMP-dependent 3',5'-cyclic phosphodiesterase

Phosphodiesterase 2A, cGMP Stimulated (PDE2A)
CCC F638
HGNC 8777
MGI 2446107
PubMed 19049345
RGD 620965
UniProt O00408
Wiki PDE2A
The PDE2A gene encodes a 941 amino acid polypeptide with a predicted molecular mass of 106 kD. The protein sequence is 90% identical to bovine and rat PDE2A sequences. Northern blot analysis showed that PDE2A was expressed as a 4.2-kb mRNA at varying levels in all human tissues tested, with greatest expression in brain. Expression studies revealed that PDE2A hydrolyzes cAMP and cGMP and is inhibited by the PDE2A-specific inhibitor EHNA.
A phosphodiesterase is any enzyme that breaks a phosphodiester bond. Usually, people speaking of phosphodiesterase are referring to cyclic nucleotide phosphodiesterases, which have great clinical significance and are described below.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 2A, cGMP Stimulated (PDE2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 2A, cGMP Stimulated (PDE2A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 2A, cGMP Stimulated (PDE2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 2A, cGMP Stimulated (PDE2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Phosphodiesterase 2A, cGMP Stimulated (PDE2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Phosphodiesterase 2A, cGMP Stimulated (PDE2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Phosphodiesterase 2A, cGMP Stimulated (PDE2A) ELISA Kit Customized Service Offer
  1. "Isolation and characterization of human cDNAs encoding a cGMP-stimulated 3',5'-cyclic nucleotide phosphodiesterase."Gene 191:89-95(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "Human chromosome 11 DNA sequence and analysis including novel gene identification." Nature 440:497-500(2006) [PubMed] [Europe PMC] [Abstract]
  4. "Dual acylation of PDE2A splice variant 3: targeting to synaptic membranes."J. Biol. Chem. 284:25782-25790(2009) [PubMed] [Europe PMC] [Abstract]
  5. "Large-scale proteomics analysis of the human kinome."Mol. Cell. Proteomics 8:1751-1764(2009) [PubMed] [Europe PMC] [Abstract]
  6. "Strategy for comprehensive identification of human N-myristoylated proteins using an insect cell-free protein synthesis system."Proteomics 10:1780-1793(2010) [PubMed] [Europe PMC] [Abstract]
  7. "A phosphodiesterase 2A isoform localized to mitochondria regulates respiration."J. Biol. Chem. 286:30423-30432(2011) [PubMed] [Europe PMC] [Abstract]
  8. "Structural determinants for inhibitor specificity and selectivity in PDE2A using the wheat germ in vitro translation system."Biochemistry 44:8312-8325(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct."Proc. Natl. Acad. Sci. U.S.A. 106:18225-18230(2009) [PubMed] [Europe PMC] [Abstract]
  10. "X-ray crystal structure of phosphodiesterase 2 in complex with a highly selective, nanomolar inhibitor reveals a binding-induced pocket important for selectivity."J. Am. Chem. Soc. 135:11708-11711(2013) [PubMed] [Europe PMC] [Abstract]