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Neural Retina Leucine Zipper (NRL)

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RP27; NRLs; NRL-MAF; Neural retina-specific leucine zipper protein

Neural Retina Leucine Zipper (NRL)
CCC F624
HGNC 8002
MGI 102567
PubMed 21865162
RGD 1305197
UniProt P54845
Wiki NRL
The protein neural retina leucine zipper (NRL) is a basic motif-leucine zipper transcription factor that is preferentially expressed in rod photoreceptors. The NRL gene encodes a putative DNA-binding protein of the 'leucine zipper' family with strong similarity to the DNA-binding domain of the MAF oncogene product. The authors suggested that the NRL gene product might play a role in the regulation of retinal development and/or differentiation.
NRL regulates the expression of several rod-specific genes, and missense mutations in the human NRL gene are associated with autosomal dominant retinitis pigmentosa. FIZ1 suppressed NRL- but not CRX -mediated transactivation of rhodopsin promoter activity in a transiently transfected monkey kidney cell line.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Retina Leucine Zipper (NRL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Retina Leucine Zipper (NRL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Retina Leucine Zipper (NRL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Retina Leucine Zipper (NRL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Retina Leucine Zipper (NRL) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Retina Leucine Zipper (NRL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Retina Leucine Zipper (NRL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Retina Leucine Zipper (NRL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Retina Leucine Zipper (NRL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Retina Leucine Zipper (NRL) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Neural Retina Leucine Zipper (NRL) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Neural Retina Leucine Zipper (NRL) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Neural Retina Leucine Zipper (NRL) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Neural Retina Leucine Zipper (NRL) CLIA Kit Customized Service Offer
n/a ELISA Kit for Neural Retina Leucine Zipper (NRL) ELISA Kit Customized Service Offer
  1. "A conserved retina-specific gene encodes a basic motif/leucine zipper domain."Proc. Natl. Acad. Sci. U.S.A. 89:266-270(1992) [PubMed] [Europe PMC] [Abstract]
  2. "Human bZIP transcription factor gene NRL: structure, genomic sequence, and fine linkage mapping at 14q11.2 and negative mutation analysis in patients with retinal degeneration."Genomics 45:395-401(1997) [PubMed] [Europe PMC] [Abstract]
  3. "Full-length transcriptome analysis of human retina-derived cell lines ARPE-19 and Y79 using the vector-capping method."Invest. Ophthalmol. Vis. Sci. 52:6662-6670(2011) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and analysis of human chromosome 14." Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "The leucine zipper of NRL interacts with the CRX homeodomain. A possible mechanism of transcriptional synergy in rhodopsin regulation."J. Biol. Chem. 275:29794-29799(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The minimal transactivation domain of the basic motif-leucine zipper transcription factor NRL interacts with TATA-binding protein."J. Biol. Chem. 279:47233-47241(2004) [PubMed] [Europe PMC] [Abstract]
  8. "A mutation in NRL is associated with autosomal dominant retinitis pigmentosa."Nat. Genet. 21:355-356(1999) [PubMed] [Europe PMC] [Abstract]
  9. "Recessive NRL mutations in patients with clumped pigmentary retinal degeneration and relative preservation of blue cone function."Proc. Natl. Acad. Sci. U.S.A. 101:17819-17824(2004) [PubMed] [Europe PMC] [Abstract]
  10. "Next-generation genetic testing for retinitis pigmentosa." Hum. Mutat. 33:963-972(2012) [PubMed] [Europe PMC] [Abstract]