Neuron Navigator 3 (NAV3)
[Edit]POMFIL1; STEERIN3; unc53H3; Pore Membrane And/Or Filament Interacting Like Protein 1; Steerin 3; Unc-53 homolog 3
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NAV3 belongs to the neuron navigator family and is expressed predominantly in the nervous system. The encoded protein contains coiled-coil domains and a conserved AAA domain characteristic for ATPases associated with a variety of cellular activities.
This gene is similar to unc-53, a Caenorhabditis elegans gene involved in axon guidance. Multiple alternatively spliced transcript variants for this gene have been described but only one has had its full-length nature determined. The deduced 1,902-amino acid protein has a calculated molecular mass of 205.3 kD. POMFIL1 contains 3 N-terminal hydrophobic domains, several phosphorylation and N-glycosylation sites, 3 ATP/GTP-binding A motifs (P loops), and coiled-coil structures.
Organism species: Homo sapiens (Human)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuron Navigator 3 (NAV3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuron Navigator 3 (NAV3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuron Navigator 3 (NAV3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuron Navigator 3 (NAV3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuron Navigator 3 (NAV3) | ELISA Kit Customized Service Offer |
Organism species: Mus musculus (Mouse)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | RPF621Mu01 | Recombinant Neuron Navigator 3 (NAV3) | Positive Control; Immunogen; SDS-PAGE; WB. |
| Antibodies | n/a | Monoclonal Antibody to Neuron Navigator 3 (NAV3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuron Navigator 3 (NAV3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuron Navigator 3 (NAV3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuron Navigator 3 (NAV3) | ELISA Kit Customized Service Offer |
Organism species: Rattus norvegicus (Rat)
| CATALOG NO. | PRODUCT NAME | APPLICATIONS | |
| Proteins | n/a | Recombinant Neuron Navigator 3 (NAV3) | Recombinant Protein Customized Service Offer |
| Antibodies | n/a | Monoclonal Antibody to Neuron Navigator 3 (NAV3) | Monoclonal Antibody Customized Service Offer |
| n/a | Polyclonal Antibody to Neuron Navigator 3 (NAV3) | Polyclonal Antibody Customized Service Offer | |
| Assay Kits | n/a | CLIA Kit for Neuron Navigator 3 (NAV3) | CLIA Kit Customized Service Offer |
| n/a | ELISA Kit for Neuron Navigator 3 (NAV3) | ELISA Kit Customized Service Offer |
- "Sensory deficits in mice hypomorphic for a mammalian homologue of unc-53."Brain Res. Dev. Brain Res. 150:89-101(2004) [PubMed] [Europe PMC] [Abstract]
- "The finished DNA sequence of human chromosome 12." Nature 440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
- "Neuron navigator: a human gene family with homology to unc-53, a cell guidance gene from Caenorhabditis elegans."Genomics 80:21-30(2002) [PubMed] [Europe PMC] [Abstract]
- "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:63-70(1999) [PubMed] [Europe PMC] [Abstract]
- "Pore membrane and/or filament interacting like protein 1 (POMFIL1) is predominantly expressed in the nervous system and encodes different protein isoforms."Gene 290:73-94(2002) [PubMed] [Europe PMC] [Abstract]
- "Primary cutaneous T-cell lymphomas show a deletion or translocation affecting NAV3, the human UNC-53 homologue." Cancer Res. 65:8101-8110(2005) [PubMed] [Europe PMC] [Abstract]
- "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]