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Methionine Sulfoxide Reductase B (MSRB)

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MSRB2; CBS-1; CBS1; CGI-131; PILB; Methionine-R-Sulfoxide Reductase B2,Mitochondrial

Methionine Sulfoxide Reductase B (MSRB)
CCC F597
HGNC 17061
MGI 1923717
PubMed 8749308
RGD 1306026
UniProt Q9Y3D2
Wiki MSRB2
Oxidation of methionine residues in proteins is mediated by various biologic oxidants such as H(2)O(2), hydroxyl radicals, hypochlorite, and superoxide ions.
Methionine sulfoxide reductase B (MSRB), is a selenoprotein. The oxidation of methionine at the sulphur atom leads to alternative epimers: R form of Met(O) and S form of Met(O). MSRB can reduce R form of both free and protein incorporated methionine sulfoxide to methionine. It has a crucial role in protecting cells against oxidative damage. MSRA reduces only the S epimer of Met(O), and MSRB reduces the R epimer of Met(O) in proteins. Although the catalytic mechanisms of MSRA and MSRB are similar, the two MSRs have no sequence identity and no structural similarity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionine Sulfoxide Reductase B (MSRB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionine Sulfoxide Reductase B (MSRB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionine Sulfoxide Reductase B (MSRB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionine Sulfoxide Reductase B (MSRB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionine Sulfoxide Reductase B (MSRB) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionine Sulfoxide Reductase B (MSRB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionine Sulfoxide Reductase B (MSRB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionine Sulfoxide Reductase B (MSRB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionine Sulfoxide Reductase B (MSRB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionine Sulfoxide Reductase B (MSRB) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Methionine Sulfoxide Reductase B (MSRB) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Methionine Sulfoxide Reductase B (MSRB) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Methionine Sulfoxide Reductase B (MSRB) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Methionine Sulfoxide Reductase B (MSRB) CLIA Kit Customized Service Offer
n/a ELISA Kit for Methionine Sulfoxide Reductase B (MSRB) ELISA Kit Customized Service Offer
  1. "Identification, expression and chromosome localization of a human gene encoding a novel protein with similarity to the pilB family of transcriptional factors (pilin) and to bacterial peptide methionine sulfoxide reductases."Gene 233:233-240(1999) [PubMed] [Europe PMC] [Abstract]
  2. "Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics."Genome Res. 10:703-713(2000) [PubMed] [Europe PMC] [Abstract]
  3. "The DNA sequence and comparative analysis of human chromosome 10." Nature 429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Methionine sulfoxide reductases B1, B2, and B3 are present in the human lens and confer oxidative stress resistance to lens cells."Invest. Ophthalmol. Vis. Sci. 46:2107-2112(2005) [PubMed] [Europe PMC] [Abstract]
  6. "Overexpression of mitochondrial methionine sulfoxide reductase B2 protects leukemia cells from oxidative stress-induced cell death and protein damage."J. Biol. Chem. 283:16673-16681(2008) [PubMed] [Europe PMC] [Abstract]
  7. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]