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Molybdenum Cofactor Synthesis 3 (MOCS3)

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UBA4; Ubiquitin-Like Modifier Activating Enzyme 4; Molybdopterin synthase sulfurylase; Molybdopterin-synthase adenylyltransferase; Molybdopterin-synthase sulfurtransferase

Molybdenum Cofactor Synthesis 3 (MOCS3)
CCC F595
HGNC 15765
MGI 1916622
PubMed 22453920
RGD 1307044
UniProt O95396
Wiki MOCS3
MOCS3 is thought to catalyze both the adenylation and subsequent generation of a thiocarboxylate group at the C terminus of the smaller subunit of molybdopterin synthase, MOCS2A.The deduced 460-amino acid protein has a calculated molecular mass of 49.7 kD. It contains an N-terminal MoeB domain and a C-terminal rhodanese (TST)-like domain (RLD). Fluorescence-tagged MOCS3 showed a cytoplasmic distribution in transfected HeLa cells.
In a defined in vitro system for the generation of molybdopterin from a precursor, the sulfurated form of MOCS3-RLD was able to provide the sulfur for the thiocarboxylation of MOCS2A. Mutation of the putative persulfide-forming active site cysteine (cys412) abolished the sulfurtransferase activity.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Synthesis 3 (MOCS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Synthesis 3 (MOCS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Synthesis 3 (MOCS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 3 (MOCS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 3 (MOCS3) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Synthesis 3 (MOCS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Synthesis 3 (MOCS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Synthesis 3 (MOCS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 3 (MOCS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 3 (MOCS3) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Synthesis 3 (MOCS3) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Synthesis 3 (MOCS3) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Synthesis 3 (MOCS3) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 3 (MOCS3) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 3 (MOCS3) ELISA Kit Customized Service Offer
  1. "Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans."Proc. Natl. Acad. Sci. U.S.A. 101:5946-5951(2004) [PubMed] [Europe PMC] [Abstract]
  2. "The DNA sequence and comparative analysis of human chromosome 20." Nature 414:865-871(2001) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Molybdenum cofactor biosynthesis in humans: identification of a persulfide group in the rhodanese-like domain of MOCS3 by mass spectrometry."Biochemistry 44:7912-7920(2005) [PubMed] [Europe PMC] [Abstract]
  5. "Site-directed mutagenesis of the active site loop of the rhodanese-like domain of the human molybdopterin synthase sulfurase MOCS3. Major differences in substrate specificity between eukaryotic and bacterial homologs."FEBS J. 274:2778-2787(2007) [PubMed] [Europe PMC] [Abstract]
  6. "A novel role for human Nfs1 in the cytoplasm: Nfs1 acts as a sulfur donor for MOCS3, a protein involved in molybdenum cofactor biosynthesis."J. Biol. Chem. 283:25178-25185(2008) [PubMed] [Europe PMC] [Abstract]
  7. "A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway."Proc. Natl. Acad. Sci. U.S.A. 105:18255-18260(2008) [PubMed] [Europe PMC] [Abstract]
  8. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Crystal structure of the human MOCS3 rhodanese-like domain."Submitted (JUL-2009) to the PDB data bank