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Molybdenum Cofactor Synthesis 2 (MOCS2)

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MCBPE; MOCO1; MOCS2A; MOCS2B; MPTS; Molybdenum cofactor synthesis protein 2 large subunit; Molybdopterin-synthase large subunit

Molybdenum Cofactor Synthesis 2 (MOCS2)
CCC F594
HGNC 7193
MGI 1336894
PubMed 21031595
RGD 1359477
UniProt O96007
Wiki MOCS2
Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits.Highest levels are found in heart and skeletal muscle. Lower levels are present in brain, kidney and pancreas. Very low levels are found in lung and peripheral blood leukocytes.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF594Hu01 Recombinant Molybdenum Cofactor Synthesis 2 (MOCS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Synthesis 2 (MOCS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Synthesis 2 (MOCS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 2 (MOCS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 2 (MOCS2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF594Mu01 Recombinant Molybdenum Cofactor Synthesis 2 (MOCS2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF594Mu01 Polyclonal Antibody to Molybdenum Cofactor Synthesis 2 (MOCS2) WB; IHC; ICC; IP.
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 2 (MOCS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 2 (MOCS2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Molybdenum Cofactor Synthesis 2 (MOCS2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Molybdenum Cofactor Synthesis 2 (MOCS2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Molybdenum Cofactor Synthesis 2 (MOCS2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Molybdenum Cofactor Synthesis 2 (MOCS2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Molybdenum Cofactor Synthesis 2 (MOCS2) ELISA Kit Customized Service Offer
  1. "Human molybdopterin synthase gene: identification of a bicistronic transcript with overlapping reading frames."Am. J. Hum. Genet. 64:698-705(1999) [PubMed] [Europe PMC] [Abstract]
  2. "The two subunits of human molybdopterin synthase: evidence for a bicistronic messenger RNA with overlapping reading frames."Nucleic Acids Res. 27:854-858(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Mechanistic studies of human molybdopterin synthase reaction and characterization of mutants identified in group B patients of molybdenum cofactor deficiency."J. Biol. Chem. 278:26127-26134(2003) [PubMed] [Europe PMC] [Abstract]
  6. "Evidence for the physiological role of a rhodanese-like protein for the biosynthesis of the molybdenum cofactor in humans."Proc. Natl. Acad. Sci. U.S.A. 101:5946-5951(2004) [PubMed] [Europe PMC] [Abstract]
  7. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  8. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
  9. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  12. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  13. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  14. "Human molybdopterin synthase gene: genomic structure and mutations in molybdenum cofactor deficiency type B."Am. J. Hum. Genet. 64:706-711(1999) [PubMed] [Europe PMC] [Abstract]
  15. "Ten novel mutations in the molybdenum cofactor genes MOCS1 and MOCS2 and in vitro characterization of a MOCS2 mutation that abolishes the binding ability of molybdopterin synthase."Hum. Genet. 117:565-570(2005) [PubMed] [Europe PMC] [Abstract]
  16. "A novel MOCS2 mutation reveals coordinated expression of the small and large subunit of molybdopterin synthase."Mol. Genet. Metab. 89:210-213(2006) [PubMed] [Europe PMC] [Abstract]