Kelch Domain Containing Protein 2 (KLHDC2)

KLHDC2 shares approximately 50% amino acid sequence identity with KLHDC1. Northern blot analysis detected a 2.0-kb KLHDC2 transcript with highest expression in skeletal muscle, moderately high expression in heart, weak expression in most other tissues tested, and no expression in peripheral blood leukocytes.

The deduced 406-amino acid KLHDC2 protein is composed almost entirely of 6 kelch repeats that form a beta-propeller structure. Northern blot analysis detected expression of KLHDC2 in all human tissues and cancer cell lines tested. KLHDC2 is primarily localized to the nucleus. The interaction with LZIP led to the repression of LZIP-dependent transcription.