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Kinesin Family, Member 2A (KIF2A)

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HK2; KIF2; KNS2; Kinesin Heavy Chain Member 2; Kinesin-2

Kinesin Family, Member 2A (KIF2A)
CCC F499
HGNC 6318
MGI 108390
PubMed 23960144
RGD 70974
UniProt O00139
Wiki KIF2A
Kinesins, such as KIF2, are microtubule-associated motor proteins. For background information on kinesins.By using cDNA differential display, Debernardi et al. (1997) isolated a kinesin heavy chain gene (KIF2) as one regulated by the synthetic retinoid HPR, a cancer chemopreventive agent and inducer of apoptotic cell death. The KIF2 gene, which they called HK2 for 'human kinesin-2,' was cloned from follicular B-cell lymphoma cells treated with HPR. Human KIF2 is a predicted 679-amino acid protein that is 97% identical to mouse KIF2 protein. On Northern blots, KIF2 was expressed as a 3.5-kb mRNA in several tissues. Debernardi et al. (1997) mapped the KIF2 gene to chromosome 5q12-q13 by PCR of a panel of radiation hybrid clones.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 2A (KIF2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 2A (KIF2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 2A (KIF2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 2A (KIF2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 2A (KIF2A) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 2A (KIF2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 2A (KIF2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 2A (KIF2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 2A (KIF2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 2A (KIF2A) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 2A (KIF2A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 2A (KIF2A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 2A (KIF2A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 2A (KIF2A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 2A (KIF2A) ELISA Kit Customized Service Offer
  1. "Identification of a novel human kinesin-related gene (HK2) by the cDNA differential display technique."Genomics 42:67-73(1997) [PubMed] [Europe PMC] [Abstract]
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  3. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  4. "The DNA sequence and comparative analysis of human chromosome 5." Nature 431:268-274(2004) [PubMed] [Europe PMC] [Abstract]
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  6. "Functional analysis of human microtubule-based motor proteins, the kinesins and dyneins, in mitosis/cytokinesis using RNA interference."Mol. Biol. Cell 16:3187-3199(2005) [PubMed] [Europe PMC] [Abstract]
  7. "The kinesin-13 proteins Kif2a, Kif2b, and Kif2c/MCAK have distinct roles during mitosis in human cells."Mol. Biol. Cell 18:2970-2979(2007) [PubMed] [Europe PMC] [Abstract]
  8. "DDA3 recruits microtubule depolymerase Kif2a to spindle poles and controls spindle dynamics and mitotic chromosome movement."J. Cell Biol. 181:255-267(2008) [PubMed] [Europe PMC] [Abstract]
  9. "Plk1 and Aurora A regulate the depolymerase activity and the cellular localization of Kif2a."J. Cell Sci. 122:1334-1341(2009) [PubMed] [Europe PMC] [Abstract]
  10. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  11. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the human KIF2 motor domain in complex with ADP."Submitted (FEB-2009) to the PDB data bank
  13. "Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly." Nat. Genet. 45:639-647(2013) [PubMed] [Europe PMC] [Abstract]