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Kinesin Family, Member 1C (KIF1C)

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LTXS1; Kinesin-like protein KIF1C

Kinesin Family, Member 1C (KIF1C)
CCC F498
HGNC 6317
MGI 1098260
PubMed 11784862
RGD 70928
UniProt O43896
Wiki KIF1C
KIF1C contains an N-terminal motor domain followed by a U104 domain. KIF1C migrated as an approximately 135-kD protein. KIF1C was expressed as a 4.2-kb mRNA in all human tissues examined, with the most abundant expression in heart and skeletal muscle. KIF1C is tyrosine-phosphorylated and associates with PTPD1 in vivo. KIF1C is localized primarily at the Golgi apparatus. Disruption of the Golgi apparatus with brefeldin A induced the flow of Golgi membranes and KIF1C to the endoplasmic reticulum. This redistribution of membranes was inhibited in cells overexpressing a catalytically inactive mutant KIF1C protein. The authors concluded that KIF1C is required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum and that tyrosine phosphorylation is a putative regulator of this transport.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 1C (KIF1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 1C (KIF1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 1C (KIF1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 1C (KIF1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 1C (KIF1C) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 1C (KIF1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 1C (KIF1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 1C (KIF1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 1C (KIF1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 1C (KIF1C) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 1C (KIF1C) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 1C (KIF1C) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 1C (KIF1C) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 1C (KIF1C) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 1C (KIF1C) ELISA Kit Customized Service Offer
  1. "Characterization of KIF1C, a new kinesin-like protein involved in vesicle transport from the Golgi apparatus to the endoplasmic reticulum."J. Biol. Chem. 273:20267-20275(1998) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:169-176(1998) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
  5. "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."Nat. Biotechnol. 24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
  6. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  7. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  9. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  10. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  11. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  12. "Crystal structure of the FHA domain of human kinesin family member C."Submitted (FEB-2006) to the PDB data bank
  13. "KIF1C mutations in two families with hereditary spastic paraparesis and cerebellar dysfunction."J. Med. Genet. 51:137-142(2014) [PubMed] [Europe PMC] [Abstract]