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Kinesin Family, Member 1B (KIF1B)

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CMT2A; CMT2; KLP; HMSNII; Klp; Kinesin-like protein KIF1B

Kinesin Family, Member 1B (KIF1B)
CCC F497
HGNC 16636
MGI 108426
PubMed 7528108
RGD 621520
UniProt O60333
Wiki KIF1B
Kif1b was expressed in all tissues tested. In situ hybridization revealed that Kif1b was expressed abundantly in differentiated nerve cells.Northern blot analysis demonstrated that human KIF1B has at least 2 isoforms. The long isoform (KIF1B-beta) was expressed in a wide variety of tissues, while the short isoform (KIF1B-alpha) was detected only in adult testis.Rotary shadowing electron microscopy revealed mostly single globular structures. Immunocytochemically, Kif1b was colocalized with mitochondria in vivo. A subcellular fractionation study showed that Kif1b was concentrated in the mitochondrial fraction, and purified Kif1b could transport mitochondria along microtubules in vitro. These data suggested that Kif1b works as a monomeric motor for anterograde transport of mitochondria.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 1B (KIF1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 1B (KIF1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 1B (KIF1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 1B (KIF1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 1B (KIF1B) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 1B (KIF1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 1B (KIF1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 1B (KIF1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 1B (KIF1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 1B (KIF1B) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 1B (KIF1B) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 1B (KIF1B) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 1B (KIF1B) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 1B (KIF1B) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 1B (KIF1B) ELISA Kit Customized Service Offer
  1. "DNA encoding a kinesin-like protein (hklp) comprising biallelic markers."Patent number WO0063375, 26-OCT-2000
  2. "Identification of the full-length KIAA0591 gene encoding a novel kinesin-related protein which is mapped to the neuroblastoma suppressor gene locus at 1p36.2."Int. J. Oncol. 16:907-916(2000) [PubMed] [Europe PMC] [Abstract]
  3. "Genomic structure and mutational analysis of the human KIF1B gene which is homozygously deleted in neuroblastoma at chromosome 1p36.2."Oncogene 20:5075-5083(2001) [PubMed] [Europe PMC] [Abstract]
  4. "Genomic structure and mutational analysis of the human KIF1Balpha gene located at 1p36.2 in neuroblastoma."Int. J. Oncol. 23:737-744(2003) [PubMed] [Europe PMC] [Abstract]
  5. "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."DNA Res. 5:31-39(1998) [PubMed] [Europe PMC] [Abstract]
  6. "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 7:143-150(2000) [PubMed] [Europe PMC] [Abstract]
  7. "The DNA sequence and biological annotation of human chromosome 1." Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  9. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  10. "The novel protein KBP regulates mitochondria localization by interaction with a kinesin-like protein."BMC Cell Biol. 6:35-35(2005) [PubMed] [Europe PMC] [Abstract]
  11. "The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressor."Genes Dev. 22:884-893(2008) [PubMed] [Europe PMC] [Abstract]
  12. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  13. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  18. "N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."Proc. Natl. Acad. Sci. U.S.A. 109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Charcot-Marie-Tooth disease type 2A caused by mutation in a microtubule motor KIF1B-beta."Cell 105:587-597(2001) [PubMed] [Europe PMC] [Abstract]