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Kinesin Family, Member 1A (KIF1A)

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ATSV; UNC104; C2orf20; Axonal Transport Of Synaptic Vesicles; Microtubule-based motor KIF1A; Unc-104- and KIF1A-related protein

Kinesin Family, Member 1A (KIF1A)
CCC F496
HGNC 888
MGI 108391
PubMed 21820098
UniProt Q12756
Wiki KIF1A
KIF1A is a member of the kinesin family. This protein is highly similar to mouse heavy chain kinesin member 1A protein which is an anterograde motor protein that transports membranous organelles along axonal microtubules. It is thought that this protein may play a critical role in the development of axonal neuropathies resulting from impaired axonal transport. There are multiple polyadenylation sites found in this gene.
This switch-like transition for movement could be shifted to lower PtdIns(4,5)P2 concentrations by the addition of cholesterol/sphingomyelin or GM1 ganglioside/cholera toxin, conditions that produced raft-like behavior of Unc104 bound to lipid bilayers. The authors concluded that clustering of Unc104 in PtdIns(4,5)P2-containing rafts provides a trigger for membrane transport.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF496Hu01 Recombinant Kinesin Family, Member 1A (KIF1A) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies PAF496Hu01 Polyclonal Antibody to Kinesin Family, Member 1A (KIF1A) WB; IHC; ICC; IP.
MAF496Hu21 Monoclonal Antibody to Kinesin Family, Member 1A (KIF1A) WB; IHC; ICC; IP.
Assay Kits SEF496Hu ELISA Kit for Kinesin Family, Member 1A (KIF1A) Enzyme-linked immunosorbent assay for Antigen Detection.

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Kinesin Family, Member 1A (KIF1A) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Kinesin Family, Member 1A (KIF1A) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Kinesin Family, Member 1A (KIF1A) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Kinesin Family, Member 1A (KIF1A) CLIA Kit Customized Service Offer
n/a ELISA Kit for Kinesin Family, Member 1A (KIF1A) ELISA Kit Customized Service Offer
  1. "Characterization of a kinesin-related gene ATSV, within the tuberous sclerosis locus (TSC1) candidate region on chromosome 9q34."Genomics 33:421-429(1996) [PubMed] [Europe PMC] [Abstract]
  2. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
  4. "The full-ORF clone resource of the German cDNA consortium."BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
  5. "KIF1A, an axonal transporter of synaptic vesicles, is mutated in hereditary sensory and autonomic neuropathy type 2." Am. J. Hum. Genet. 89:219-230(2011) [PubMed] [Europe PMC] [Abstract]
  6. "Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability." Am. J. Hum. Genet. 88:306-316(2011) [PubMed] [Europe PMC] [Abstract]
  7. Erratum Am. J. Hum. Genet. 88:516-516(2011)
  8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
  9. "Exome sequencing and disease-network analysis of a single family implicate a mutation in KIF1A in hereditary spastic paraparesis."Genome Res. 21:658-664(2011) [PubMed] [Europe PMC] [Abstract]