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Intersectin 2 (ITSN2)

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SWAP; SWA; SH3D1B; SH3 Domain Protein 1B; SH3P18-Like WASP Associated Protein

Intersectin 2 (ITSN2)
CCC F492
HGNC 6184
MGI 1338049
PubMed 22449706
RGD 1590890
UniProt Q9NZM3
Wiki ITSN2
Intersectin-2 is thought to regulate the formation of clathrin-coated vesicles and also may function in the induction of T cell antigen receptor (TCR) endocytosis. Alternatively spliced transcript variants have been found for this gene that encode three distinct isoforms. Additional variants have been found but their full length nature has not been determined. The partial SH3D1B cDNA encodes a predicted adaptor-like protein containing at least 3 SH3 domains. SH3 domains are 60-amino acid regions of limited sequence similarity among a number of signaling and cytoskeletal proteins. Despite their modest similarity, SH3 domains share a common function: they mediate protein-protein interactions by binding short proline-rich regions in target proteins.

Organism species: Homo sapiens (Human)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF492Hu01 Recombinant Intersectin 2 (ITSN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Intersectin 2 (ITSN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intersectin 2 (ITSN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intersectin 2 (ITSN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intersectin 2 (ITSN2) ELISA Kit Customized Service Offer

Organism species: Mus musculus (Mouse)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins RPF492Mu01 Recombinant Intersectin 2 (ITSN2) Positive Control; Immunogen; SDS-PAGE; WB.
Antibodies n/a Monoclonal Antibody to Intersectin 2 (ITSN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intersectin 2 (ITSN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intersectin 2 (ITSN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intersectin 2 (ITSN2) ELISA Kit Customized Service Offer

Organism species: Rattus norvegicus (Rat)

CATALOG NO. PRODUCT NAME APPLICATIONS
Proteins n/a Recombinant Intersectin 2 (ITSN2) Recombinant Protein Customized Service Offer
Antibodies n/a Monoclonal Antibody to Intersectin 2 (ITSN2) Monoclonal Antibody Customized Service Offer
n/a Polyclonal Antibody to Intersectin 2 (ITSN2) Polyclonal Antibody Customized Service Offer
Assay Kits n/a CLIA Kit for Intersectin 2 (ITSN2) CLIA Kit Customized Service Offer
n/a ELISA Kit for Intersectin 2 (ITSN2) ELISA Kit Customized Service Offer
  1. "Intersectin 2, a new multimodular protein involved in clathrin-mediated endocytosis."FEBS Lett. 478:43-51(2000) [PubMed] [Europe PMC] [Abstract]
  2. "Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."DNA Res. 6:337-345(1999) [PubMed] [Europe PMC] [Abstract]
  3. "Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Nature 434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs." Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
  5. "Cloning of ligand targets: systematic isolation of SH3 domain-containing proteins."Nat. Biotechnol. 14:741-744(1996) [PubMed] [Europe PMC] [Abstract]
  6. "The human intersectin genes and their spliced variants are differentially expressed."Biochim. Biophys. Acta 1521:1-11(2001) [PubMed] [Europe PMC] [Abstract]
  7. "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry."Anal. Chem. 76:2763-2772(2004) [PubMed] [Europe PMC] [Abstract]
  8. "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."Nat. Biotechnol. 23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
  9. "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."J. Proteome Res. 7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
  10. "A quantitative atlas of mitotic phosphorylation."Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]
  11. "Identification of SH3 domain interaction partners of human FasL (CD178) by phage display screening."BMC Immunol. 10:53-53(2009) [PubMed] [Europe PMC] [Abstract]
  12. "Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins."J. Cell. Biochem. 108:877-885(2009) [PubMed] [Europe PMC] [Abstract]
  13. "Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits."Mol. Biol. Cell 20:3251-3260(2009) [PubMed] [Europe PMC] [Abstract]
  14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
  15. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
  16. "FCHo proteins are nucleators of clathrin-mediated endocytosis."Science 328:1281-1284(2010) [PubMed] [Europe PMC] [Abstract]
  17. "Initial characterization of the human central proteome."BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
  18. "The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin beta1 endocytosis."Mol. Biol. Cell 23:2905-2916(2012) [PubMed] [Europe PMC] [Abstract]
  19. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
  20. "Solution structure of SH3 domains of human intersectin 2 (KIAA1256)."Submitted (AUG-2004) to the PDB data bank